3-BroMo-5-(trifluoroMethyl)anisole

Base Information

• Chemical Name: 3-BroMo-5-(trifluoroMethyl)anisole
• CAS No.: 627527-23-5
• Molecular Formula: C8H6BrF3O
• Molecular Weight: 255.034
• Hs Code.: 2909309090
• Mol file: 627527-23-5.mol

Synonyms:3-Bromo-5-(trifluoromethyl)anisole;1-bromo-3-methoxy-5-trifluoromethyl-benzene;

Chemical Property of 3-BroMo-5-(trifluoroMethyl)anisole

Chemical Property:

• Boiling Point: 201℃
• Flash Point: 93℃
• PSA: 9.23000
• Density: 1.563
• LogP: 3.47650
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-3-methoxy-5-(trifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BroMo-5-(trifluoroMethyl)anisole

There total 4 articles about 3-BroMo-5-(trifluoroMethyl)anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-(trifluoromethyl)-m-anisidine (349-55-3) → 1-bromo-3-methoxy-5-(trifluoromethyl)benzene (627527-23-5)

Guidance literature:

With sulfuric acid; hydrogen bromide; copper(I) bromide; sodium nitrite; In acetic acid; at 0 - 20 ℃;

Reference yield:

3-bromo-5-(trifluoromethyl)phenol (1025718-84-6) + methyl iodide (74-88-4) → 1-bromo-3-methoxy-5-(trifluoromethyl)benzene (627527-23-5)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 3h;

Reference yield:

2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (479411-93-3) → 1-bromo-3-methoxy-5-(trifluoromethyl)benzene (627527-23-5)

Guidance literature:

With copper(ll) bromide; In methanol; at 80 ℃;

DOI:10.1021/ja076498n

upstream raw materials:

2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

5-(trifluoromethyl)-m-anisidine

3-bromo-5-(trifluoromethyl)phenol

methyl iodide

Downstream raw materials:

N-[3-methoxy-5-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-5-[(phenylmethoxy)methyl]-1H-pyrazol-3-amine

3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-methanol

3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetic acid methyl ester

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