3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

Base Information

Chemical Name:3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile
CAS No.:1274885-09-4
Molecular Formula:C₁₉H₁₆F₃N₅O
Molecular Weight:387.364
Hs Code.:

Synonyms:3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

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Chemical Property of 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

Chemical Property:

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Technology Process of 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

There total 8 articles about 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: 1274885-08-3
3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-methanol

: 1274885-09-4
3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

Guidance literature:: 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-methanol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

sodium cyanide; In tetrahydrofuran; dimethyl sulfoxide; for 1h; Reflux; Inert atmosphere;

Reference yield:

: 773837-37-9
sodium cyanide

: C₁₉H₁₉F₃N₄O₄S

: 1274885-09-4
3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

Guidance literature:: In tetrahydrofuran; dimethyl sulfoxide; for 1h; Reflux; Inert atmosphere;

Reference yield:

: 627527-23-5
1-bromo-3-methoxy-5-(trifluoromethyl)benzene

: 1274885-09-4
3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 2 h / 110 °C / Microwave irradiation

2.1: manganese(IV) oxide / dichloromethane / 6 h / 20 °C

3.1: boron tribromide / dichloromethane / 1 h / -10 °C / Inert atmosphere

4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 3 h / 20 °C

4.2: 1 h / Reflux; Inert atmosphere

With manganese(IV) oxide; boron tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;