Carbamic acid, (2-hydroxyethyl)-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

Base Information

Chemical Name:Carbamic acid, (2-hydroxyethyl)-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester
CAS No.:629921-36-4
Molecular Formula:C26H28F7N3O4
Molecular Weight:579.515
Hs Code.:

Carbamic acid, (2-hydroxyethyl)-,
(2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl
]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

Synonyms:

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Chemical Property of Carbamic acid, (2-hydroxyethyl)-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

Chemical Property:

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Technology Process of Carbamic acid, (2-hydroxyethyl)-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester

There total 3 articles about Carbamic acid, (2-hydroxyethyl)-, (2R,4S)-1-[[[[3,5-bis(trifluoromethyl)phenyl]methyl]methylamino]carbonyl ]-2-(4-fluoro-2-methylphenyl)-4-piperidinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 629922-66-3
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

: 141-43-5
ethanolamine

: 1885-14-9
phenyl chloroformate

: 629921-36-4
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(2-hydroxyethylaminocarbonyloxy)piperidine

Guidance literature:: (2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}amino-carbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine; phenyl chloroformate; With pyridine; In dichloromethane; at 0 - 20 ℃; for 19.5h;

ethanolamine; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 26h;

Reference yield:

: 629955-38-0
(2R,4S)-2-(4-fluoro-2-methyl-phenyl)-4-(2-hydroxyethylaminocarbonyloxy)piperidine

: 629956-38-3
N-(3,5-bistrifluoromethylbenzyl)-N-methyl-aminocarbonyl chloride

: 629921-36-4
(2R,4S)-1-{N-(3,5-bistrifluoromethylbenzyl)-N-methyl}aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-(2-hydroxyethylaminocarbonyloxy)piperidine

Guidance literature:: (2R,4S)-2-(4-fluoro-2-methyl-phenyl)-4-(2-hydroxyethylaminocarbonyloxy)piperidine; N-(3,5-bistrifluoromethylbenzyl)-N-methyl-aminocarbonyl chloride; With potassium carbonate; In Isopropyl acetate; water; at 60 ℃; for 21h;

In n-heptane; isopropyl alcohol; at 10 - 40 ℃; for 1h;