5-(benzyloxy)-2-tert-butylpyridine

Base Information

• Chemical Name: 5-(benzyloxy)-2-tert-butylpyridine
• CAS No.: 1196074-15-3
• Molecular Formula: C16H19NO
• Molecular Weight: 241.333
• Mol file: 1196074-15-3.mol

Synonyms:5-(benzyloxy)-2-tert-butylpyridine

Chemical Property of 5-(benzyloxy)-2-tert-butylpyridine

Chemical Property:

• Boiling Point: 352.0±30.0 °C(Predicted)
• PSA: 22.12000
• Density: 1.031±0.06 g/cm3(Predicted)
• LogP: 3.95810

Purity/Quality:

99% ^*data from raw suppliers

5-(Benzyloxy)-2-tert-butylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(benzyloxy)-2-tert-butylpyridine

There total 4 articles about 5-(benzyloxy)-2-tert-butylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(benzyloxy)-2-bromopyridine (630120-99-9) + tert-butylmagnesium chloride (677-22-5) → 2-(1,1-dimethylethyl)-5-[(phenylmethyl)oxy]pyridine (1196074-15-3)

Guidance literature:

tert-butylmagnesium chloride; With copper(l) cyanide; In tetrahydrofuran; at -78 ℃; for 0.25h;

5-(benzyloxy)-2-bromopyridine; In tetrahydrofuran; at -78 - 30 ℃; for 22h;

Reference yield:

benzyl bromide (100-39-0) → 2-(1,1-dimethylethyl)-5-[(phenylmethyl)oxy]pyridine (1196074-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 25 - 30 °C

1.2: 48 h / 15 - 30 °C

2.1: copper(l) cyanide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 22 h / -78 - 30 °C

With copper(l) cyanide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

6-bromo-pyridin-3-ol (55717-45-8,55717-40-3) → 2-(1,1-dimethylethyl)-5-[(phenylmethyl)oxy]pyridine (1196074-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 25 - 30 °C

1.2: 48 h / 15 - 30 °C

2.1: copper(l) cyanide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 22 h / -78 - 30 °C

With copper(l) cyanide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

5-(benzyloxy)-2-bromopyridine

tert-butylmagnesium chloride

benzyl bromide

6-bromo-pyridin-3-ol

Downstream raw materials:

2-tert-butyl-5-hydroxypyridine