4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one

Base Information

Chemical Name:4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one
CAS No.:436088-67-4
Molecular Formula:C10H9ClN2O2
Molecular Weight:224.647
Hs Code.:2933990090
European Community (EC) Number:888-952-0
DSSTox Substance ID:DTXSID70389834
Wikidata:Q82186030
ChEMBL ID:CHEMBL4779058
Mol file:436088-67-4.mol

Synonyms:436088-67-4;4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one;4-(2-Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one;4-(2-chloroacetyl)-1,3-dihydroquinoxalin-2-one;4-(2-CHLOROACETYL)-1,2,3,4-TETRAHYDROQUINOXALIN-2-ONE;4-(2-chloroacetyl)-3,4-dihydro-1h-quinoxalin-2-one;4-(chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one;CHEMBL4779058;SCHEMBL11035331;DTXSID70389834;MFCD00522774;AKOS000300479;MB01296;LS-07629;CS-0219572;FT-0676683;EN300-04361;SR-01000313985;J-513291;SR-01000313985-1;Z56886550;F0838-0626

Suppliers and Price of 4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one
50mg
$ 90.00

Matrix Scientific
4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one
1g
$ 378.00

Crysdot
4-(2-Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one 97%
5g
$ 874.00

Chemenu
4-(2-Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one 97%
5g
$ 825.00

Biosynth Carbosynth
4-(Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one
1 g
$ 255.00

Biosynth Carbosynth
4-(Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one
500 mg
$ 150.00

Biosynth Carbosynth
4-(Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one
250 mg
$ 85.00

Biosynth Carbosynth
4-(Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one
5 g
$ 868.00

Biosynth Carbosynth
4-(Chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one
2 g
$ 434.00

American Custom Chemicals Corporation
4-(2-CHLORO-ACETYL)-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE 95.00%
5G
$ 1548.26

Total 8 raw suppliers

Chemical Property of 4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one

Chemical Property:

Vapor Pressure:7.52E-11mmHg at 25°C
Melting Point:0oC
Boiling Point:0°C
Flash Point:0°C
PSA：49.41000
Density:1.382g/cm³
LogP:1.41350
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:224.0352552
Heavy Atom Count:15
Complexity:283

Purity/Quality:

98%min ^*data from raw suppliers

4-(chloroacetyl)-3,4-dihydroquinoxalin-2(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC2=CC=CC=C2N1C(=O)CCl

Technology Process of 4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one

There total 4 articles about 4-(2-Chloro-acetyl)-3,4-dihydro-1H-quinoxalin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 59564-59-9
1,2,3,4-tetrahydroquinoxalin-2-one

: 79-04-9
chloroacetyl chloride

: 436088-67-4
4-(2-chloroacetyl)-3,4-dihydroquinoxalin-2-(1H)-one

Guidance literature:: 1,2,3,4-tetrahydroquinoxalin-2-one; chloroacetyl chloride; With triethylamine; In ethyl acetate; for 1h; Reflux;

With potassium carbonate; In ethyl acetate; for 0.25h;
DOI:10.1016/j.ejmech.2019.111987

Reference yield:

: 5427-99-6
2-((2-nitrophenyl)amino)acetic acid

: 436088-67-4
4-(2-chloroacetyl)-3,4-dihydroquinoxalin-2-(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(ll) chloride; hydrogenchloride / ethanol / 2 h / Reflux

2.1: triethylamine / ethyl acetate / 1 h / Reflux

2.2: 0.25 h

With hydrogenchloride; triethylamine; tin(ll) chloride; In ethanol; ethyl acetate;
DOI:10.1016/j.ejmech.2019.111987

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 436088-67-4
4-(2-chloroacetyl)-3,4-dihydroquinoxalin-2-(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyrographite; potassium carbonate / 0.27 h / 120 °C / Microwave irradiation

2.1: tin(ll) chloride; hydrogenchloride / ethanol / 2 h / Reflux

3.1: triethylamine / ethyl acetate / 1 h / Reflux

3.2: 0.25 h

With hydrogenchloride; potassium carbonate; pyrographite; triethylamine; tin(ll) chloride; In ethanol; ethyl acetate;
DOI:10.1016/j.ejmech.2019.111987