5427-99-6

Basic information

• Product Name: N-o-nitrophenylglycine
• Synonyms: N-o-nitrophenylglycine;N-(2-Nitrophenyl)glycine
• CAS NO: 5427-99-6
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• Mol File: 5427-99-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 192 °C (decomp)
• Boiling Point: 449.5°C at 760 mmHg
• Flash Point: 225.7°C
• Appearance: /
• Density: 1.487g/cm³
• Vapor Pressure: 7.24E-09mmHg at 25°C
• Refractive Index: 1.658
• PKA: 4.18±0.10(Predicted)
• CAS DataBase Reference: N-o-nitrophenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-o-nitrophenylglycine(5427-99-6)
• EPA Substance Registry System: N-o-nitrophenylglycine(5427-99-6)

Safety Data

• Hazardous Substances Data: 5427-99-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2O4/c11-8(12)5-9-6-3-1-2-4-7(6)10(13)14/h1-4,9H,5H2,(H,11,12)

Upstream product

• 88-74-4 2-nitro-aniline 
• 598-21-0 2-Bromoacetyl bromide 
• 105-36-2 ethyl bromoacetate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 56-40-6 glycine 
• 5428-05-7 n-(2-nitrophenyl)glycine ethyl ester 
• 79-11-8 chloroacetic acid 
• 127-09-3 sodium acetate 

Downstream Products

• 121163-60-8 N-(2-nitro-phenyl)-N-nitroso-glycine 
• 4937-77-3 4-(phenylsulfonyl)-3,4-dihydroquinoxalin-2(1H)-one 
• 436088-67-4 4-(2-chloroacetyl)-3,4-dihydroquinoxalin-2-(1H)-one 
• 4937-75-1 4-benzoyl-1,2,3,4-tetrahydroquinoxalin-2-one 
• 120589-86-8 4-acetyl-3,4-dihydroquinoxalin-2(1H)-one 
• 86532-26-5 <2-18F>Fluoronitrobenzene 
• 389065-48-9 methyl 2-((2-nitrophenyl)amino)acetate 
• 1029320-21-5 C₁₆H₁₇N₃O₃ 
• 18916-43-3 Benzimidazol-N-oxid 
• 5428-05-7 n-(2-nitrophenyl)glycine ethyl ester 

Relevant articles and documents

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SUBSTITUTED BENZIMIDAZOLIUM, PYRIDO-IMIDAZOLIUM, OR PYRAZINO-IMIDAZOLIUM COMPOUNDS AS CHEMOTHERAPEUTICS

Provided herein are compounds of the formula:(I) wherein: R1, R2, R3, R4, R5, X, A1, A2, A3, and A4 are as defined herein. In some aspects, these compounds may be used to treat cancer and other hyperproliferative disease. In some aspects, compositions, methods of treatment, and methods of synthesis are also provided herein.

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs. The observed selectivity and potency (IC50 values 10-200 nM against HDAC6) is markedly dependent on the absolute configuration of the chiral moiety, and suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.