(2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol

Base Information

Chemical Name:(2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol
CAS No.:63121-18-6
Molecular Formula:C9H22O3Si
Molecular Weight:206.357
Hs Code.:
DSSTox Substance ID:DTXSID40543623
Nikkaji Number:J1.225.891G
Wikidata:Q82420557

Synonyms:63121-18-6;(R)-3-((tert-Butyldimethylsilyl)oxy)propane-1,2-diol;(2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol;DTXSID40543623

Suppliers and Price of (2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol

Chemical Property:

PSA：49.69000
LogP:1.36140
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:206.13382109
Heavy Atom Count:13
Complexity:151

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC(CO)O
Isomeric SMILES:CC(C)(C)[Si](C)(C)OC[C@@H](CO)O

Technology Process of (2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol

There total 4 articles about (2R)-3-{[tert-Butyl(dimethyl)silyl]oxy}propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 56-81-5,25618-55-7,64333-26-2,8013-25-0
glycerol

: 85951-09-3
2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecan-6-ol

: 63121-18-6
(R)-3-((tert-butyldimethylsilyl)oxy)propane-1,2-diol

Guidance literature:: With 1,2,2,6,6-pentamethylpiperidine; (2R,4S)-3-((R)-cyclopentyl(1-methyl-1H-imidazol-2-yl)methyl)-4-isopropyl-2-methoxyoxazolidine; Pempidine hydrochloride; In tetrahydrofuran; at 4 ℃; for 12h; Reagent/catalyst; Time; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc33633b

Reference yield: 47.0%

: 114413-26-2,123237-62-7,124150-87-4,78906-15-7
tert-butyldimethylsilyl glycidyl ether

: 78906-15-7,114413-26-2,124150-87-4,123237-62-7
tert-butyldimethylsilyl (S)-glycidyl ether

: 63121-18-6
(R)-3-((tert-butyldimethylsilyl)oxy)propane-1,2-diol

Guidance literature:: With (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); air; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1021/ja016737l

Reference yield: 47.0%

: 114413-26-2,123237-62-7,124150-87-4,78906-15-7
tert-butyldimethylsilyl glycidyl ether

: 78906-15-7,114413-26-2,124150-87-4,123237-62-7
tert-butyldimethylsilyl (S)-glycidyl ether

: 63121-18-6
(R)-3-((tert-butyldimethylsilyl)oxy)propane-1,2-diol

: (S)-3-((tert-butyldimethylsilyl)oxy)propane-1,2-diol

Guidance literature:: With (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); air; acetic acid; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ja016737l