5,8-Dimethylquinoline

Base Information

• Chemical Name: 5,8-Dimethylquinoline
• CAS No.: 2623-50-9
• Molecular Formula: C11H11 N
• Molecular Weight: 157.215
• Hs Code.: 2933499090
• European Community (EC) Number: 220-078-1
• DSSTox Substance ID: DTXSID10180867
• Nikkaji Number: J47.680C
• Wikidata: Q63395495
• Mol file: 2623-50-9.mol

Synonyms:5,8-DIMETHYLQUINOLINE;2623-50-9;Quinoline, 5,8-dimethyl-;EINECS 220-078-1;5,8-dimethyl-quinoline;SCHEMBL812451;DTXSID10180867;AKOS006371968;Q63395495

Chemical Property of 5,8-Dimethylquinoline

Chemical Property:

• Vapor Pressure: 0.00992mmHg at 25°C
• Melting Point: 2.3°C
• Refractive Index: 1.6102 (estimate)
• Boiling Point: 272.8°Cat760mmHg
• PKA: 5.27±0.29(Predicted)
• Flash Point: 112.9°C
• PSA: 12.89000
• Density: 1.052g/cm³
• LogP: 2.85160
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

99% ^*data from raw suppliers

5,8-dimethyl-Quinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CC=NC2=C(C=C1)C

Technology Process of 5,8-Dimethylquinoline

There total 5 articles about 5,8-Dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,5-Dimethylaniline (95-78-3) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 5,8-dimethylquinoline (2623-50-9)

Guidance literature:

With sulfuric acid; sodium iodide; at 140 - 145 ℃; for 2.5h;

DOI:10.1055/s-1989-27423

Reference yield: 40.0%

2,5-Dimethylaniline (95-78-3) + propan-1-ol-3-amine (156-87-6) → 5,8-dimethylquinoline (2623-50-9)

Guidance literature:

With ruthenium trichloride; triphenylphosphine; tin(ll) chloride; In 1,4-dioxane; acetone; at 180 ℃; for 20h;

DOI:10.1002/jhet.5570360510

Reference yield:

arsenic pentoxide hydrate (As2 O5.xH2 O) + 2,5-Dimethylaniline (95-78-3) → quinoline (91-22-5) + 5,8-dimethylquinoline (2623-50-9)

Guidance literature:

With ammonium hydroxide; In sulfuric acid; acetic acid; glycerol;

upstream raw materials:

2,5-Dimethylaniline

glycerol

propan-1-ol-3-amine

Downstream raw materials:

8-methyl-5-quinolinecarboxylic acid

glyoxime

8-methyl-pyrido[2,3-d][1,2]oxazin-5-one

2,3-Diacetylpyridin