methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

Base Information

Chemical Name:methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate
CAS No.:63492-81-9
Molecular Formula:C₁₁H₁₃NO₂
Molecular Weight:191.23
Hs Code.:
DSSTox Substance ID:DTXSID501213362
Nikkaji Number:J2.880.931J

Synonyms:63492-81-9;2-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester, (2R)-;SCHEMBL8567081;methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate;DTXSID501213362;Methyl (2R)-1,2,3,4-tetrahydro-2-quinolinecarboxylate;1,2,3,4-Tetrahydroquinoline-2beta-carboxylic acid methyl ester

Suppliers and Price of methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.094628657
Heavy Atom Count:14
Complexity:217

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CCC2=CC=CC=C2N1
Isomeric SMILES:COC(=O)[C@H]1CCC2=CC=CC=C2N1

Technology Process of methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

There total 34 articles about methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 19575-07-6
quinoline-2-carboxylic acid methyl ester

: 63492-81-9
methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

Guidance literature:: With diiodo(p-cymene)ruthenium(II) dimer; Bis(p-nitrophenyl) phosphate; hydrogen; C₂₃H₁₉N; In ethyl acetate; at 60 ℃; for 48h; under 25858.1 Torr; Reagent/catalyst; Solvent; Temperature; enantioselective reaction; Catalytic behavior; Autoclave; Schlenk technique;
DOI:10.1021/acs.orglett.1c03430

Reference yield: 46.0%

: 63430-79-5
1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester

: 63492-82-0
methyl (2S)-1,2,3,4-tetrahydroquinoline-2-carboxylate

: 63492-81-9
methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

Guidance literature:: With Chiralpak IA 20 μm; In methanol; Resolution of racemate; Large scale;
DOI:10.1021/acs.oprd.9b00364

Reference yield:

: 19575-07-6
quinoline-2-carboxylic acid methyl ester

: 63492-82-0
methyl (2S)-1,2,3,4-tetrahydroquinoline-2-carboxylate

: 63492-81-9
methyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate

Guidance literature:: With (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole; bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; iodine; In toluene; at 20 ℃; for 17h; under 37503.8 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;
DOI:10.1016/j.tetlet.2012.06.114