4-Methoxy-2-indolinone

Base Information

• Chemical Name: 4-Methoxy-2-indolinone
• CAS No.: 7699-17-4
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.176
• Hs Code.: 2933990090
• Mol file: 7699-17-4.mol

Synonyms:2-Indolinone,4-methoxy- (7CI,8CI);4-Methoxy-1,3-dihydro-2H-indol-2-one;4-Methoxy-1,3-dihydroindol-2-one;4-Methoxy-2(3H)-indolone;4-Methoxy-2-oxindole;4-Methoxyindolin-2-one;4-Methoxyoxindole;

Chemical Property of 4-Methoxy-2-indolinone

Chemical Property:

• Vapor Pressure: 3.14E-05mmHg at 25°C
• Melting Point: 196 °C
• Refractive Index: 1.564
• Boiling Point: 355.4 °C at 760 mmHg
• PKA: 13.79±0.20(Predicted)
• Flash Point: 168.7 °C
• PSA: 38.33000
• Density: 1.208 g/cm³
• LogP: 1.32780
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxyoxindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-2-indolinone

There total 11 articles about 4-Methoxy-2-indolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(2-methoxy-6-nitrophenyl)acetic acid (20876-28-2) → 4-methoxyindolin-2-one (7699-17-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In acetic acid; at 20 ℃; for 16h;

Reference yield: 85.0%

3-(2-methoxybenzyl)-1,4,2-dioxazol-5-one → 4-methoxyindolin-2-one (7699-17-4)

Guidance literature:

With 8-quinolinol; sodium tetrafluoroborate; carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; silver carbonate; at 20 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.202001254

Reference yield: 12.0%

7-methoxy-3-methyl-3-thiomethyl oxindole (86915-04-0) → 7-methoxy-3-methyl-1H-indole (83696-96-2) + 4-methoxyindolin-2-one (7699-17-4) + 4-methoxyisatin (108937-87-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)81948-6

upstream raw materials:

2-(2-methoxy-6-nitrophenyl)acetic acid

7-methoxy-3-methyl-3-thiomethyl oxindole

2-nitro-6-methoxybenzyl bromide

(6-methoxy-2-nitrophenyl)acetonitrile

Downstream raw materials:

4-methoxy-1-methyloxindole

4-Hydroxy-oxindol

4-methoxy-1-methyl-1H-indole

4-methoxy-2-oxoindoline-3-spirocyclopentane