1-Piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester
• CAS No.: 644982-86-5
• Molecular Formula: C22H28FNO6
• Molecular Weight: 421.466
• Mol file: 644982-86-5.mol

Synonyms:1,1-dimethylethyl 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-1-piperidinecarboxylate;

Chemical Property of 1-Piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 82.14000
• LogP: 3.48460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-1-piperidinecarboxylate (796113-35-4) + 4-flourophenylmagnesium bromide (352-13-6) → 1-piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-1,1-dimethyl ester (644982-86-5)

Guidance literature:

copper(l) iodide; In tetrahydrofuran; at 0 - 23 ℃; for 3h;

Reference yield:

1-piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-1,1-dimethyl ester (644982-86-5) → [1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid (644981-80-6)

Guidance literature:

With water; In pentan-3-one; at 102 ℃; for 24h;

Reference yield:

1-piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-1,1-dimethyl ester (644982-86-5) + glycine ethyl ester hydrochloride (852880-78-5) → 1,1-dimethylethyl 4-{2-{[(3,5-dichlorophenyl)-methyl]-[2-(ethyloxy)-2-oxoethyl]-amino}-1-[(methyloxy)-carbonyl]-2-oxoethyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate (852880-79-6)

Guidance literature:

1-piperidinecarboxylic acid, 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(4-fluorophenyl)-1,1-dimethyl ester; glycine ethyl ester hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 - 55 ℃; for 2.5 - 3.75h;

With potassium carbonate; dimethyl sulfate; In DMF (N,N-dimethyl-formamide); at 20 ℃;

upstream raw materials:

1,1-dimethylethyl 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-1-piperidinecarboxylate

4-flourophenylmagnesium bromide

Downstream raw materials:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid

1,1-dimethylethyl 4-(4-fluorophenyl)-4-[2-oxo-2-(2-propen-1-yloxy)-ethyl]-1-piperidinecarboxylate

1,1-dimethylethyl 4-{2-{[(3,5-dichlorophenyl)-methyl]-[2-(ethyloxy)-2-oxoethyl]-amino}-1-[(methyloxy)-carbonyl]-2-oxoethyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate