n-Methyl-1-(2-nitrophenyl)methanamine hydrochloride

Base Information

• Chemical Name: n-Methyl-1-(2-nitrophenyl)methanamine hydrochloride
• CAS No.: 5441-60-1
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.1772
• European Community (EC) Number: 844-505-1
• Mol file: 5441-60-1.mol

Synonyms:5441-60-1;n-methyl-1-(2-nitrophenyl)methanamine hydrochloride;N-methyl-N-(2-nitrobenzyl)amine hydrochloride;N-Methyl-2-nitrobenzylamine Hydrochloride;N-methyl-1-(2-nitrophenyl)methanamine;hydrochloride;methyl[(2-nitrophenyl)methyl]amine hydrochloride;MFCD09971668;N-Methyl-N-(2-nitrobenzyl)amine HCl;Benzenemethanamine, N-methyl-2-nitro-, monohydrochloride;AKOS024462784;SB77809;AM806003;AS-70214;SY096680;CS-0036735;EN300-33545;A924096;n-methyl-1-(2-nitrophenyl)methanaminehydrochloride;Z361993844

Chemical Property of n-Methyl-1-(2-nitrophenyl)methanamine hydrochloride

Chemical Property:

• Boiling Point: 251.4°Cat760mmHg
• Flash Point: 105.8°C
• Density: 1.162g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.0509053
• Heavy Atom Count: 13
• Complexity: 156

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCC1=CC=CC=C1[N+](=O)[O-].Cl

Technology Process of n-Methyl-1-(2-nitrophenyl)methanamine hydrochloride

There total 4 articles about n-Methyl-1-(2-nitrophenyl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-nitrobenzyl chloride (612-23-7) + methylamine (74-89-5) → N-methyl-1-(2-nitrophenyl)methanamine hydrochloride (5441-60-1) + methyl-bis-(2-nitro-benzyl)-amine; hydrochloride (117535-90-7)

Guidance literature:

In methanol; water; for 0.75h; Heating;

Reference yield: 57.0%

methylamine hydrochloride (593-51-1) + 2-nitro-benzaldehyde (552-89-6) → N-methyl-1-(2-nitrophenyl)methanamine hydrochloride (5441-60-1)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 110 ℃; for 0.183333h; Microwave irradiation;

DOI:10.1055/s-0030-1258298

Reference yield:

2-nitro-benzaldehyde (552-89-6) → N-methyl-1-(2-nitrophenyl)methanamine hydrochloride (5441-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 15.35 g / H₂O / 0.25 h

2: 1.) NaBH₄, 2.) hydrochloric acid / 1.) ethanol, room temp., 4 h., 2.) ether

With hydrogenchloride; sodium tetrahydroborate; In water;

upstream raw materials:

2-nitrobenzyl chloride

methylamine

Methyl-[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amine

2-nitro-benzaldehyde

Downstream raw materials:

N-methyl-N-(2-nitrobenzyl)carbamoyl chloride

C₁₇H₁₉ClN₂O₂

2-amino-N-methylbenzylamine hydrochloride

Refernces

• 1、 Zara-Kaczian, Erzsebet,Deak, Gyula,Gyoergy, Lajos. "POTENTIAL CNS ACTIVE 1-ARYL-2-AMINO-1-ETHANOL DERIVATIVES". . p. 441 - 454. Retrieved 2007/10/02.