2H-1,3-Diazepin-2-one, 1,3-bis[(2-chlorophenyl)methyl]hexahydro-5,6-di hydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-

Base Information

Chemical Name:2H-1,3-Diazepin-2-one, 1,3-bis[(2-chlorophenyl)methyl]hexahydro-5,6-di hydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS No.:153182-55-9
Molecular Formula:C₃₃H₃₂Cl₂N₂O₃
Molecular Weight:575.535
Hs Code.:
Mol file:153182-55-9.mol

Synonyms:2H-1,3-Diazepin-2-one,1,3-bis[(2-chlorophenyl)methyl]hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-,[4R-(4a,5a,6b,7b)]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1,3-Diazepin-2-one, 1,3-bis[(2-chlorophenyl)methyl]hexahydro-5,6-di hydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-

Chemical Property:

Vapor Pressure:1.18E-22mmHg at 25°C
Boiling Point:734.6°C at 760 mmHg
Flash Point:398.1°C
PSA：64.01000
Density:1.326g/cm³
LogP:6.25140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1,3-Diazepin-2-one, 1,3-bis[(2-chlorophenyl)methyl]hexahydro-5,6-di hydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-

There total 6 articles about 2H-1,3-Diazepin-2-one, 1,3-bis[(2-chlorophenyl)methyl]hexahydro-5,6-di hydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58917-85-4
N-(benzyloxycarbonyl)-D-phenylalaninol

: 153182-55-9
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-(2-chloro-benzyl)-5,6-dihydroxy-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) CH₂Cl₂, -70 deg C, 2 h

2: 55 percent / VCl₃*(THF)3, Zn / CH₂Cl₂

3: 91 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C

4: 52 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

5: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 2 h

6: HCl / methanol; dioxane

With hydrogenchloride; oxalyl dichloride; Vanadium (III) chloride-(tris-tetrahydrofuran); hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571

Reference yield:

: 63219-70-5
N-(benzyloxycarbonyl)-D-phenylalaninal

: 153182-55-9
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-(2-chloro-benzyl)-5,6-dihydroxy-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / VCl₃*(THF)3, Zn / CH₂Cl₂

2: 91 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C

3: 52 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

4: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 2 h

5: HCl / methanol; dioxane

With hydrogenchloride; Vanadium (III) chloride-(tris-tetrahydrofuran); hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571

Reference yield:

: 183814-19-9
((1S,2R,3S,4R)-1-Benzyl-4-benzyloxycarbonylamino-2,3-dihydroxy-5-phenyl-pentyl)-carbamic acid benzyl ester

: 153182-55-9
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-(2-chloro-benzyl)-5,6-dihydroxy-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / diisopropylethylamine / dimethylformamide / 48 h / 50 °C

2: 52 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

3: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 2 h

4: HCl / methanol; dioxane

With hydrogenchloride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9602571