Chemical Property of Esmolol
Chemical Property:
- Vapor Pressure:3.62E-08mmHg at 25°C
- Melting Point:48-50 ºC
- Boiling Point:430.2 °C at 760 mmHg
- PKA:13.88±0.20(Predicted)
- Flash Point:214 °C
- PSA：67.79000
- Density:1.026
- LogP:1.92080
- Water Solubility.:Slightly soluble
- XLogP3:1.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:10
- Exact Mass:295.17835828
- Heavy Atom Count:21
- Complexity:288
- Purity/Quality:
-
99% *data from raw suppliers
Esmolol *data from reagent suppliers
Safty Information:
- Pictogram(s):
A reproductive hazard.
- Hazard Codes:A reproductive hazard.
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Beta-Adrenergic Receptor Antagonists
- Canonical SMILES:CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O
- Recent ClinicalTrials:Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study
- Recent EU Clinical Trials:Postoperative effects of high-dose esmolol during mitral valve surgery for mitral regurgitation.
- Recent NIPH Clinical Trials:Comparing three drugs for reducing heart rate and blood pressure during laryngoscopy andintubation
-
Uses
Esmolol is a cardioselective beta1 receptor blocking agent. Agricultural chemical.
-
Therapeutic Function
Beta-adrenergic blocker
-
Clinical Use
Esmolol (Brevibloc) is a short-acting intravenously administered
β1-selective adrenoceptor blocking agent. It
does not possess membrane-stabilizing activity or sympathomimetic
activity.
Esmolol is used in the treatment of supraventricular
tachyarrhythmias for rapid control of ventricular rate
and reduction of myocardial oxygen consumption.
Discontinuation of administration is followed by a rapid
reversal of its pharmacological effects because of esmolol’s
rapid hydrolysis by plasma esterases.
