2-Methyl-1,2,3,4-tetrahydroquinolin-6-amine

Base Information

• Chemical Name: 2-Methyl-1,2,3,4-tetrahydroquinolin-6-amine
• CAS No.: 649569-61-9
• Molecular Formula: C10H14N2
• Molecular Weight: 162.235
• DSSTox Substance ID: DTXSID30595919

Synonyms:649569-61-9;2-Methyl-1,2,3,4-tetrahydroquinolin-6-amine;1,2,3,4-Tetrahydro-2-methyl-6-quinolinamine;6-Quinolinamine, 1,2,3,4-tetrahydro-2-methyl-;SCHEMBL9394761;DTXSID30595919;ZAB56961;MFCD13179161;AKOS027255384;AS-66721;6-amino-2-methyl-1,2,3,4-tetrahydroquinoline;W10064

Chemical Property of 2-Methyl-1,2,3,4-tetrahydroquinolin-6-amine

Chemical Property:

• Boiling Point: 337.3±31.0 °C(Predicted)
• PSA: 38.05000
• Density: 1.049±0.06 g/cm3(Predicted)
• LogP: 2.73460
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 162.115698455
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

1,2,3,4-Tetrahydro-2-methyl-6-quinolinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCC2=C(N1)C=CC(=C2)N

Technology Process of 2-Methyl-1,2,3,4-tetrahydroquinolin-6-amine

There total 1 articles about 2-Methyl-1,2,3,4-tetrahydroquinolin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylquinolin-6-amine (65079-19-8) → 2-methyl-1,2,3,4-tetrahydro-quinolin-6-ylamine (649569-61-9)

Guidance literature:

With sulfuric acid; hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1016/j.bmcl.2003.07.029

Reference yield:

2-methyl-1,2,3,4-tetrahydro-quinolin-6-ylamine (649569-61-9) → (R)-6-((S)-5-Aminomethyl-2-oxo-oxazolidin-3-yl)-2-methyl-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: NaHCO₃ / acetone

2: n-BuLi / tetrahydrofuran

3: Et₃N / CH₂Cl₂

4: aq. NH₃ / acetonitrile; propan-2-ol

With ammonium hydroxide; n-butyllithium; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2003.07.029

Reference yield:

2-methyl-1,2,3,4-tetrahydro-quinolin-6-ylamine (649569-61-9) → benzyl (2R)-6-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate (312306-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / acetone

2: n-BuLi / tetrahydrofuran

With n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; acetone;

DOI:10.1016/j.bmcl.2003.07.029

upstream raw materials:

2-methylquinolin-6-amine

Downstream raw materials:

benzyl 6-{[(benzyloxy)carbonyl]amino}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

benzyl (2R)-6-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

Benzyl (2R)-6-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

benzyl (2R)-6-{(5S)-5-[(ethanethioylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

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