Technology Process of Ethanethioic acid,
S-[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro-5-methyl-2,4-diox
o-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl] ester
There total 12 articles about Ethanethioic acid,
S-[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro-5-methyl-2,4-diox
o-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl] ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
DOI:10.1002/hlca.200390243
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 96 percent / H2; quinoline / Lindlar catalyst / ethyl acetate
2.1: tetraisopropyl orthotitanate; (+)-diisopropyl L-tartrate; t-BuOOH / CH2Cl2 / -50 - -20 °C
2.2: 4.0 g / diethyl ether; tetrahydrofuran / 1 h / -50 °C
3.1: 87 percent / pyridine / CH2Cl2 / 20 °C
4.1: osmium tetroxide; 4-methylmorpholine 4-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 20 °C
5.1: sodium metaperiodate / tetrahydrofuran; H2O / 0.5 h
6.1: 6.2 g / Dowex 50*8 / 1.5 h / 20 °C
7.1: 98 percent / H2 / 10 percent Pd/C / methanol / 4 h
8.1: 32 percent / N-methyl-N-(trimethylsilyl)trifluoroacetamide; trimethylsilyl triflate / acetonitrile / 8 h / 20 °C
9.1: 83 percent / DMAP; pyridine / 5 h / 20 °C
10.1: 94 percent / Bu4NF / tetrahydrofuran / 2.5 h
11.1: 90 percent / PPh3; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C
With
pyridine; quinoline; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; sodium periodate; osmium(VIII) oxide; L-(+)-diisopropyl tartrate; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; Dowex 50*8; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; triphenylphosphine;
palladium on activated charcoal; Lindlar's catalyst;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
11.1: Mitsunobu reaction;
DOI:10.1002/hlca.200390243
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetraisopropyl orthotitanate; (+)-diisopropyl L-tartrate; t-BuOOH / CH2Cl2 / -50 - -20 °C
1.2: 4.0 g / diethyl ether; tetrahydrofuran / 1 h / -50 °C
2.1: 87 percent / pyridine / CH2Cl2 / 20 °C
3.1: osmium tetroxide; 4-methylmorpholine 4-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 20 °C
4.1: sodium metaperiodate / tetrahydrofuran; H2O / 0.5 h
5.1: 6.2 g / Dowex 50*8 / 1.5 h / 20 °C
6.1: 98 percent / H2 / 10 percent Pd/C / methanol / 4 h
7.1: 32 percent / N-methyl-N-(trimethylsilyl)trifluoroacetamide; trimethylsilyl triflate / acetonitrile / 8 h / 20 °C
8.1: 83 percent / DMAP; pyridine / 5 h / 20 °C
9.1: 94 percent / Bu4NF / tetrahydrofuran / 2.5 h
10.1: 90 percent / PPh3; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C
With
pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; sodium periodate; osmium(VIII) oxide; L-(+)-diisopropyl tartrate; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; Dowex 50*8; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
10.1: Mitsunobu reaction;
DOI:10.1002/hlca.200390243
