Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)-

Base Information

Chemical Name:Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)-
CAS No.:651027-09-7
Molecular Formula:C13H17BrF2O2Si
Molecular Weight:351.263
Hs Code.:
DSSTox Substance ID:DTXSID00460701
Wikidata:Q82284849

Synonyms:Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)-;651027-09-7;DTXSID00460701

Suppliers and Price of Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)-

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:350.01493
Heavy Atom Count:19
Complexity:318

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC[Si](CC)(CC)C1=C(C(=C(C=C1F)Br)C(=O)O)F

Technology Process of Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)-

There total 5 articles about Benzoic acid, 6-bromo-2,4-difluoro-3-(triethylsilyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 651027-04-2
(3,5-dibromo-2,6-difluorophenyl)triethylsilane

: 651027-09-7
2-bromo-4,6-difluoro-5-(triethylsilyl)benzoic acid

Guidance literature:: With n-butyllithium; In diethyl ether; hexane; at -100 ℃; for 0.25h;
DOI:10.1002/ejoc.200300354

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 651027-05-3
(3,4-dibromo-2,6-difluorophenyl)triethylsilane

: 651027-09-7
2-bromo-4,6-difluoro-5-(triethylsilyl)benzoic acid

Guidance literature:: With n-butyllithium; In diethyl ether; hexane; at -100 ℃; for 0.25h;
DOI:10.1002/ejoc.200300354

Reference yield:

: 994-30-9
triethylsilyl chloride

: 651027-09-7
2-bromo-4,6-difluoro-5-(triethylsilyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C

2: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h

3: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C

4: butyllithium / hexane; diethyl ether / 0.25 h / -100 °C

With n-butyllithium; bromine; sec.-butyllithium; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; cyclohexane;
DOI:10.1002/ejoc.200300354