3-Hydroxystearic acid ethyl ester

Base Information

• Chemical Name: 3-Hydroxystearic acid ethyl ester
• CAS No.: 65144-03-8
• Molecular Formula: C20H40O3
• Molecular Weight: 328.536
• Hs Code.: 2918199090
• Mol file: 65144-03-8.mol

Synonyms:Octadecanoic acid,3-hydroxy-,ethyl ester;3-hydroxy-octadecanoic acid ethyl ester;ethyl-3-hydroxy octadecanoate;Ethyl-3-hydroxyoctadecanoat;3-Hydroxy-octadecansaeure-aethylester;

Chemical Property of 3-Hydroxystearic acid ethyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 5.78180

Purity/Quality:

Ethyl3-Hydroxyoctadecanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 3-Hydroxyoctadecanoate is an intermediate in the synthesis of 3-Hydroxystearoylcarnitine Hydrochloride (H953630), which is found in overweight patients.

Technology Process of 3-Hydroxystearic acid ethyl ester

There total 6 articles about 3-Hydroxystearic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-oxooctadecanoate (62625-23-4) → ethyl 3-hydroxyoctadecanoate (65144-03-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃;

DOI:10.1002/cmdc.201800720

Reference yield:

1-hexadecylcarboxylic acid (57-10-3) → ethyl 3-hydroxyoctadecanoate (65144-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 20 °C

With sodium tetrahydroborate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol;

DOI:10.1002/cmdc.201800720

Reference yield:

ethanol (64-17-5) + 3-hydroxyoctadecanoic acid (17773-30-7) → ethyl 3-hydroxyoctadecanoate (65144-03-8)

Guidance literature:

With sulfuric acid;

upstream raw materials:

ethanol

3-hydroxyoctadecanoic acid

ethyl 3-oxooctadecanoate

n-hexadecylaldehyde

Downstream raw materials:

(E)-2-octadecenoic acid

3-hydroxyoctadecanoic acid

trans-octadec-2-en-1-ol

methyl trans-2-octadecenoate

Refernces

• 1、 -. "Method for preparation of sphingoid bases". . . Retrieved 2008/06/13.