(11S,14S)-Cyclo-(L-Trp-L-Phe)

Base Information

Chemical Name:(11S,14S)-Cyclo-(L-Trp-L-Phe)
CAS No.:6521-48-8
Molecular Formula:C₂₀H₁₉N₃O₂
Molecular Weight:333.39
Hs Code.:
DSSTox Substance ID:DTXSID901017851
Nikkaji Number:J577.378D
Wikidata:Q27136723
Metabolomics Workbench ID:125279
ChEMBL ID:CHEMBL190059
Mol file:6521-48-8.mol

Synonyms:Isorugulosuvine;(11S,14S)-Cyclo-(L-Trp-L-Phe);Cyclo(-Phe-Trp);CHEBI:68230;(3S,6S)-3-benzyl-6-(1H-indol-3-ylmethyl)piperazine-2,5-dione;6521-48-8;Cyclo(Phe-Trp-);Cyclo(L-Trp-L-Phe);MLS002704309;CHEMBL190059;DTXSID901017851;HY-P5051;MFCD00237619;SMR001571011;CS-0675894;C22142;Q27136723

Suppliers and Price of (11S,14S)-Cyclo-(L-Trp-L-Phe)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (11S,14S)-Cyclo-(L-Trp-L-Phe)

Chemical Property:

Melting Point:254.5 - 256.5 °C
PSA：73.99000
LogP:2.59390
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:333.147726857
Heavy Atom Count:25
Complexity:503

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC2C(=O)NC(C(=O)N2)CC3=CNC4=CC=CC=C43
Isomeric SMILES:C1=CC=C(C=C1)C[C@H]2C(=O)N[C@H](C(=O)N2)CC3=CNC4=CC=CC=C43

Technology Process of (11S,14S)-Cyclo-(L-Trp-L-Phe)

There total 17 articles about (11S,14S)-Cyclo-(L-Trp-L-Phe) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 35661-40-6
N-Fmoc L-Phe

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 82597-82-8,92842-17-6,6521-48-8
cyclo(L-tryptophyl-L-phenylalanyl)

Guidance literature:: N-Fmoc L-Phe; (S)-tryptophan methyl ester hydrochloride; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With piperidine; In acetonitrile; for 22h;
DOI:10.1039/C7CC00555E