methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate

Base Information

Chemical Name:methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate
CAS No.:653563-78-1
Molecular Formula:C12H16O4
Molecular Weight:224.257
Hs Code.:
DSSTox Substance ID:DTXSID60475513
Wikidata:Q82306095

Synonyms:653563-78-1;methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate;SCHEMBL3240321;DTXSID60475513

Suppliers and Price of methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:224.10485899
Heavy Atom Count:16
Complexity:233

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(C)(C(=O)OC)OC1=CC=C(C=C1)O
Isomeric SMILES:CC[C@](C)(C(=O)OC)OC1=CC=C(C=C1)O

Technology Process of methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate

There total 7 articles about methyl (2R)-2-(4-hydroxyphenoxy)-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 587832-07-3
(+)-methyl-2-[4-phenylmethoxy-phenoxy]-2-methyl butyrate

: 653563-78-1
R-(+)-2-(4-hydroxyphenoxy)-2-methyl butyric acid methyl ester

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 0.75h; Product distribution / selectivity; Heating / reflux;

Reference yield: 88.0%

: 67-56-1
methanol

: 908150-18-5
(R)-2-[4-phenylmethoxyphenoxy]-2-methyl butyric acid R-(-)-phenylglycinol salt

: 653563-78-1
R-(+)-2-(4-hydroxyphenoxy)-2-methyl butyric acid methyl ester

Guidance literature:: With sulfuric acid; at 25 - 35 ℃; for 13 - 20h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 653563-74-7
methyl 2-(4-(benzyloxy)phenoxy)butanoate

: 653563-78-1
R-(+)-2-(4-hydroxyphenoxy)-2-methyl butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / -78 °C

2: H₂ / Pd/C

3: chiral resolution using Chiracel OJ column

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.12.022