2-Furancarboxylic acid, 5-[[[6-[[(1R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino] -2-[(phenylmethyl)thio]-4-pyrimidinyl]amino]sulfonyl]-

Base Information

Chemical Name:2-Furancarboxylic acid, 5-[[[6-[[(1R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino] -2-[(phenylmethyl)thio]-4-pyrimidinyl]amino]sulfonyl]-
CAS No.:654074-56-3
Molecular Formula:C25H34N4O6S2Si
Molecular Weight:578.786
Hs Code.:

2-Furancarboxylic acid,
5-[[[6-[[(1R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino]
-2-[(phenylmethyl)thio]-4-pyrimidinyl]amino]sulfonyl]-

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Chemical Property of 2-Furancarboxylic acid, 5-[[[6-[[(1R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino] -2-[(phenylmethyl)thio]-4-pyrimidinyl]amino]sulfonyl]-

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Technology Process of 2-Furancarboxylic acid, 5-[[[6-[[(1R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino] -2-[(phenylmethyl)thio]-4-pyrimidinyl]amino]sulfonyl]-

There total 5 articles about 2-Furancarboxylic acid, 5-[[[6-[[(1R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino] -2-[(phenylmethyl)thio]-4-pyrimidinyl]amino]sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 654074-55-2
methyl 5-[({2-(benzylthio)-6-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]pyrimidin-4-yl}amino)sulfonyl]-2-furoate

: 654074-56-3
5-[({2-(benzylthio)-6-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]pyrimidin-4-yl}amino)sulfonyl]-2-furoic acid

Guidance literature:: methyl 5-[({2-(benzylthio)-6-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]pyrimidin-4-yl}amino)sulfonyl]-2-furoate; With lithium hydroxide; water; In tetrahydrofuran; for 1h;

With acetic acid; In water;

Reference yield:

: (2R)-2-{[6-amino-2-(benzylthio)pyrimidin-4-yl]amino}propan-1-ol

: 654074-56-3
5-[({2-(benzylthio)-6-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]pyrimidin-4-yl}amino)sulfonyl]-2-furoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 48 h

2: pyridine / dmap / 36 h

3: lithium hydroxide; water / tetrahydrofuran / 1 h

With pyridine; 1H-imidazole; lithium hydroxide; water; dmap; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);

Reference yield:

: 654072-59-0
2-(benzylthio)-N-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)pyrimidine-4,6-diamine

: 654074-56-3
5-[({2-(benzylthio)-6-[((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)amino]pyrimidin-4-yl}amino)sulfonyl]-2-furoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dmap / 36 h

2: lithium hydroxide; water / tetrahydrofuran / 1 h

With pyridine; lithium hydroxide; water; dmap; In tetrahydrofuran;