1-(2,4-dimethoxyphenyl)butane-1,3-dione

Base Information

• Chemical Name: 1-(2,4-dimethoxyphenyl)butane-1,3-dione
• CAS No.: 65547-54-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 65547-54-8.mol

Synonyms:1-(2,4-Dimethoxy-phenyl)-butane-1,3-dione;1-(2,4-Dimethoxy-phenyl)-butan-1,3-dion;2.4-Dimethoxybenzoylaceton;o,p-Dimethoxybenzoylacetone;

Chemical Property of 1-(2,4-dimethoxyphenyl)butane-1,3-dione

Chemical Property:

• Melting Point: 58.5 °C
• Boiling Point: 368.3±27.0 °C(Predicted)
• PKA: 9.57±0.23(Predicted)
• PSA: 52.60000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: 1.86560

Purity/Quality:

99% ^*data from raw suppliers

1-(2,4-dimethoxyphenyl)butane-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4-dimethoxyphenyl)butane-1,3-dione

There total 4 articles about 1-(2,4-dimethoxyphenyl)butane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4 dimethoxybenzoic acid (91-52-1) → 1-(2,4-Dimethoxyphenyl)-1,3-butanedione (65547-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.50 g / oxalyl chloride / diethyl ether / 2 h / Heating

2: 1) iPr₂NLi (LDA) / 1) THF, -78 deg C, 20 min, 2) THF, -78 deg C to -60 deg C, 1 h

With oxalyl dichloride; lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo00041a026

Reference yield:

2,4-dimethoxybenzoyl chloride (39828-35-8) + acetone (67-64-1) → 1-(2,4-Dimethoxyphenyl)-1,3-butanedione (65547-54-8)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, -78 deg C, 20 min, 2) THF, -78 deg C to -60 deg C, 1 h;

DOI:10.1021/jo00041a026

Reference yield:

ethyl acetate (141-78-6) → 1-(2,4-Dimethoxyphenyl)-1,3-butanedione (65547-54-8)

Guidance literature:

With diethyl ether; sodium;

upstream raw materials:

2,4-dimethoxybenzoyl chloride

acetone

ethyl acetate

2,4 dimethoxybenzoic acid

Downstream raw materials:

8-Chloro-1-(2,4-dimethoxyphenyl)-7-octene-1,3-dione

2-(2,4-Dimethoxy-benzoyl)-3-methyl-4H-benzo[1,4]thiazine-6-sulfonic acid

2-(5,6-Dihydro-imidazo[2,1-b]thiazol-3-yl)-1-(2,4-dimethoxy-phenyl)-ethanone; hydrobromide

2-[5,6-Dihydro-imidazo[2,1-b]thiazol-(3E)-ylidene]-1-(2,4-dimethoxy-phenyl)-ethanone

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