Methyl 2-cyano-3-(4-methoxyphenyl)acrylate

Base Information

• Chemical Name: Methyl 2-cyano-3-(4-methoxyphenyl)acrylate
• CAS No.: 65576-66-1
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224

Synonyms:2-cyano-3-(4-methoxy-phenyl)-acrylic acid methyl ester;METHYL 2-CYANO-3-(4-METHOXYPHENYL)ACRYLATE;methyl-α-cyano-4-methoxycinnamate;

Chemical Property of Methyl 2-cyano-3-(4-methoxyphenyl)acrylate

Chemical Property:

• PSA: 59.32000
• LogP: 1.77518

Purity/Quality:

98%min ^*data from raw suppliers

methyl2-cyano-3-(4-methoxyphenyl)prop-2-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-cyano-3-(4-methoxyphenyl)acrylate

There total 8 articles about Methyl 2-cyano-3-(4-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

p-Anisaldehyde dimethyl acetal (2186-92-7) + methyl 2-cyanoacetate (105-34-0) → methyl 2-cyano-3-(4-methoxyphenyl)propenoate (65576-66-1)

Guidance literature:

With sulfuric acid; ethylenediamine; at 50 ℃; for 3h;

DOI:10.1039/c8cc07644h

Reference yield: 98.3%

→ methyl 2-cyano-3-(4-methoxyphenyl)propenoate (65576-66-1)

Guidance literature:

With ruthenium-carbon composite; at 160 ℃; for 4h;

Reference yield: 92.0%

4-methoxy-benzaldehyde (123-11-5) + methyl 2-cyanoacetate (105-34-0) → methyl 2-cyano-3-(4-methoxyphenyl)propenoate (65576-66-1)

Guidance literature:

With polyguanidine PG 2; In water; at 20 ℃; for 0.5h;

DOI:10.1071/CH12507

upstream raw materials:

3-(4-methoxyphenyl)-2-nitro-1-phenyl-2-propen-1-one

methyl 2-cyanoacetate

1-(4-methoxyphenyl)-2-nitro-1-buten-3-one

4-methoxy-benzaldehyde

Downstream raw materials:

5-amino-2-(4-methoxy-benzylidene)-7-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6,8-dicarboxylic acid dimethyl ester

methyl 2-cyano-3-(4-methoxyphenyl)propionate

methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carboxylate

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