[[2-Nitro-5-(propylthio)phenyl]thiocarbamoyl]carbamic acid methyl ester

Base Information

• Chemical Name: [[2-Nitro-5-(propylthio)phenyl]thiocarbamoyl]carbamic acid methyl ester
• CAS No.: 65671-10-5
• Molecular Formula: C12H15N3O4S2
• Molecular Weight: 329.401
• Mol file: 65671-10-5.mol

Synonyms:N-methoxycarbonyl-N'-(2-nitro-5-propylthiophenyl)thiourea;

Chemical Property of [[2-Nitro-5-(propylthio)phenyl]thiocarbamoyl]carbamic acid methyl ester

Chemical Property:

• PSA: 153.57000
• LogP: 4.13680
• Solubility.: Acetonitrile, Chloroform

Purity/Quality:

99% ^*data from raw suppliers

N-[[[2-Nitro-5-(propylthio)phenyl]amino]thioxomethyl]carbamicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-[[[2-Nitro-5-(propylthio)phenyl]amino]thioxomethyl]carbamic Acid Methyl Ester is an intermediate in the synthesis of Netobimin (N390900), a phenylguanidine anthelmintic agent.

Technology Process of [[2-Nitro-5-(propylthio)phenyl]thiocarbamoyl]carbamic acid methyl ester

There total 5 articles about [[2-Nitro-5-(propylthio)phenyl]thiocarbamoyl]carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-nitro-5-n-propylthioaniline (57780-75-3) + potassium thioacyanate (333-20-0) + methyl chloroformate (79-22-1) → 1-(3-carbomethoxythioureido)-2-nitro-5-propylthiobenzene (65671-10-5)

Guidance literature:

In acetone;

DOI:10.1016/0960-894X(96)00405-2

Reference yield:

N-(5-chloro-2-nitrophenyl)acetamide (5443-33-4) → 1-(3-carbomethoxythioureido)-2-nitro-5-propylthiobenzene (65671-10-5)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / Heating

2: KOH / ethane-1,2-diol

3: 48 percent / acetone

With potassium hydroxide; sulfuric acid; In ethylene glycol; acetone;

DOI:10.1016/0960-894X(96)00405-2

Reference yield:

methoxycarbonylisothiocyanate (35266-49-0) + 2-nitro-5-n-propylthioaniline (57780-75-3) → 1-(3-carbomethoxythioureido)-2-nitro-5-propylthiobenzene (65671-10-5)

Guidance literature:

In acetonitrile;

upstream raw materials:

methoxycarbonylisothiocyanate

2-nitro-5-n-propylthioaniline

potassium thioacyanate

methyl chloroformate

Downstream raw materials:

C₂₀H₂₃N₃O₂S₂

C₁₉H₂₀N₄O₄S₂

C₂₂H₂₅N₃O₂S₂

C₂₀H₂₂N₄O₄S₂