DIMETHYL BENZYLMALONATE

Base Information

• Chemical Name: DIMETHYL BENZYLMALONATE
• CAS No.: 65749-05-5
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 65749-05-5.mol

Synonyms:2-methyl-2-phenylmalonic acid dimethyl ester;dimethyl 2-phenyl-2-methylmalonate;phenylhydrazono-malonic acid dimethyl ester;dimethyl 2-oxopropanedioate phenylhydrazone;Mesoxalsaeure-dimethylester-phenylhydrazon;Dimethyl-methylphenyl-malonat;

Chemical Property of DIMETHYL BENZYLMALONATE

Chemical Property:

• Boiling Point: 144-147 °C(Press: 9 Torr)
• PSA: 52.60000
• Density: 1.133±0.06 g/cm3(Predicted)
• LogP: 1.19130

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dimethyl2-benzylmalonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYL BENZYLMALONATE

There total 8 articles about DIMETHYL BENZYLMALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

dimethyl 2-phenylmalonate (37434-59-6) + carbonic acid dimethyl ester (616-38-6) → 2-methyl-2-phenylmalonic acid dimethyl ester (65749-05-5) + benzeneacetic acid methyl ester (101-41-7)

Guidance literature:

With potassium carbonate; In methanol; at 160 ℃; for 3h; Further Variations:; Temperatures; time; Product distribution;

DOI:10.1021/jo0057699

Reference yield: 21.0%

phenylacetonitrile (140-29-4) → 2-methyl-2-phenylmalonic acid dimethyl ester (65749-05-5)

Guidance literature:

DOI:10.1016/S0957-4166(00)86155-8

Reference yield:

phenyl benzyl ketone (451-40-1) + carbonic acid dimethyl ester (616-38-6) → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + 2-phenylpropionic acid methyl ester (31508-44-8) + 2-methyl-2-phenylmalonic acid dimethyl ester (65749-05-5) + benzeneacetic acid methyl ester (101-41-7)

Guidance literature:

With potassium carbonate; at 200 ℃; for 6.5h; Title compound not separated from byproducts;

upstream raw materials:

phenylacetonitrile

phenyl benzyl ketone

carbonic acid dimethyl ester

2-phenyl-1-p-tolyl-ethanone

Downstream raw materials:

(+)-(R)-2-methyl-2-phenylmalonic acid monomethyl ester

(±)-2-methyl-2-phenylmalonic acid monomethyl ester

5-methyl-5-phenylbarbituric acid

Refernces

• 1、 Foley, Louise H,Palermo, Robert,Dunten, Pete,Wang, Ping. "Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors". . p. 969 - 972. Retrieved 2007/10/03.
• 2、 Miyamoto, Kenji,Tsuchiya, Shigeo,Ohta, Hiromichi. "Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives". . p. 225 - 232. Retrieved 2007/10/02.