3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol

Base Information

Chemical Name:3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol
CAS No.:660390-78-3
Molecular Formula:C15H23FO2
Molecular Weight:254.345
Hs Code.:
DSSTox Substance ID:DTXSID801185065

Synonyms:SCHEMBL16512751;3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol;DTXSID801185065;660390-78-3

Suppliers and Price of 3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:254.16820813
Heavy Atom Count:18
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=CC(=C(C(=C1O)CO)F)C(C)(C)C

Technology Process of 3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol

There total 15 articles about 3,5-Bis(1,1-dimethylethyl)-2-fluoro-6-hydroxybenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 2923-83-3
4,6-di(tert-butyl)-3-fluorophenol

: 660390-78-3
3,5-di(tert-butyl)-6-fluorosalicyl alcohol

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 72h;
DOI:10.1002/ejoc.200300537

Reference yield:

: 660390-76-1
1-[5-(6,8-di-tert-butyl-5-fluoro-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-2,5-dihydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 3056-17-5
stavudin

: 660390-78-3
3,5-di(tert-butyl)-6-fluorosalicyl alcohol

Guidance literature:: With phosphate buffer; at 37 ℃; pH=7.3; Product distribution;
DOI:10.1002/ejoc.200300537

Reference yield:

: 372-20-3
3-fluorophenol

: 660390-78-3
3,5-di(tert-butyl)-6-fluorosalicyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / H₂SO₄ / 1 h / 40 °C

2: 71 percent / aq. NaOH / methanol / 72 h / 20 °C

With sodium hydroxide; sulfuric acid; In methanol;
DOI:10.1021/jm031032a