Carbamic acid, [[6-[4-[(methoxymethylamino)carbonyl]-2-thiazolyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[6-[4-[(methoxymethylamino)carbonyl]-2-thiazolyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:660450-97-5
Molecular Formula:C32H38N4O4S
Molecular Weight:574.744
Hs Code.:

Carbamic acid,
[[6-[4-[(methoxymethylamino)carbonyl]-2-thiazolyl]-4-(4-methylphenyl)-2-
(2-methylpropyl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [[6-[4-[(methoxymethylamino)carbonyl]-2-thiazolyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [[6-[4-[(methoxymethylamino)carbonyl]-2-thiazolyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [[6-[4-[(methoxymethylamino)carbonyl]-2-thiazolyl]-4-(4-methylphenyl)-2- (2-methylpropyl)-3-quinolinyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 660449-99-0
2-(3-(((tert-butoxycarbonyl)amino)methyl)-2-isobutyl-4-(4-methylphenyl)quinolin-6-yl)-1,3-thiazole-4-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 660450-97-5
tert-butyl ((2-isobutyl-6-(4-(methoxy(methyl)carbamoyl)-1,3-thiazol-2-yl)-4-(4-methylphenyl)quinolin-3-yl)methyl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2017.05.048

Reference yield:

: 660449-04-7
tert-butyl {[6-hydroxy-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 660450-97-5
tert-butyl ((2-isobutyl-6-(4-(methoxy(methyl)carbamoyl)-1,3-thiazol-2-yl)-4-(4-methylphenyl)quinolin-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.1: bis(pinacol)diborane; potassium acetate / dimethyl sulfoxide / 0.17 h / 80 °C / Inert atmosphere

2.2: 0.25 h / 100 °C / Inert atmosphere

2.3: 17 h / Inert atmosphere; Reflux

3.1: sodium hydroxide / methanol; tetrahydrofuran / 0.25 h / 20 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium acetate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis(pinacol)diborane; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling / 2.3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2017.05.048

Reference yield:

: 660449-16-1
3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl trifluoromethanesulfonate

: 660450-97-5
tert-butyl ((2-isobutyl-6-(4-(methoxy(methyl)carbamoyl)-1,3-thiazol-2-yl)-4-(4-methylphenyl)quinolin-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(pinacol)diborane; potassium acetate / dimethyl sulfoxide / 0.17 h / 80 °C / Inert atmosphere

1.2: 0.25 h / 100 °C / Inert atmosphere

1.3: 17 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / methanol; tetrahydrofuran / 0.25 h / 20 °C

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis(pinacol)diborane; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling / 1.3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2017.05.048