Ethyl 2-(m-tolyloxy)acetate

Base Information

• Chemical Name: Ethyl 2-(m-tolyloxy)acetate
• CAS No.: 66047-01-6
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• ChEMBL ID: CHEMBL1163910
• DSSTox Substance ID: DTXSID50546488
• Nikkaji Number: J59.924G
• Wikidata: Q82424340
• Mol file: 66047-01-6.mol

Synonyms:66047-01-6;ethyl 2-(m-tolyloxy)acetate;ETHYL 2-(3-METHYLPHENOXY)ACETATE;ETHYL (3-METHYLPHENOXY)ACETATE;(3-methylphenoxy)acetic acid ethyl ester;CHEMBL1163910;(3-METHYLPHENOXY) ACETIC ACID ETHYL ESTER;ethyl2-(m-tolyloxy)acetate;Ethyl 3-methylphenoxyacetate;SCHEMBL6494581;DTXSID50546488;BDBM50321270;AKOS008947814;AB08349;FS-5190;(3-METHYLPHENOXY)ACETICACIDETHYLESTER;CS-0331453

Chemical Property of Ethyl 2-(m-tolyloxy)acetate

Chemical Property:

• PSA: 35.53000
• LogP: 1.93690
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-(3-Methylphenoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=CC(=C1)C
• Uses: Ethyl 2-(3-methylphenoxy)acetate is used as a reagent to synthesize oxadiazole-isopropylamides, which act as potent and noncovalent proteasome inhibitors.

Technology Process of Ethyl 2-(m-tolyloxy)acetate

There total 8 articles about Ethyl 2-(m-tolyloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl bromoacetate (105-36-2) + 3-methyl-phenol (108-39-4) → ethyl 3-methylphenoxyacetate (66047-01-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1021/jm400221d

Reference yield: 93.0%

→ ethyl 3-methylphenoxyacetate (66047-01-6)

Guidance literature:

Reference yield: 80.0%

chloroacetic acid ethyl ester (105-39-5) + 3-methyl-phenol (108-39-4) → ethyl 3-methylphenoxyacetate (66047-01-6)

Guidance literature:

With potassium carbonate; In acetone; for 8h; Reflux;

DOI:10.1016/j.bmc.2010.11.034

upstream raw materials:

ethyl iodide

Sodium; m-tolyloxy-acetate

ethyl bromoacetate

3-methyl-phenol

Downstream raw materials:

2-(m-methylphenoxy)acetohydroxamic acid

m-tolyloxy-acetic acid hydrazide

2-(m-tolyloxy)acetic acid

2-(m-tolyloxy)acetyl chloride