7-bromo-6-methoxyIsoquinoline

Base Information

• Chemical Name: 7-bromo-6-methoxyIsoquinoline
• CAS No.: 666735-07-5
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.08100
• Mol file: 666735-07-5.mol

Synonyms:Isoquinoline,7-bromo-6-methoxy;

Chemical Property of 7-bromo-6-methoxyIsoquinoline

Chemical Property:

• Boiling Point: 346.1±22.0 °C(Predicted)
• PKA: 5.34±0.10(Predicted)
• PSA: 22.12000
• Density: 1.516±0.06 g/cm3(Predicted)
• LogP: 3.00590

Purity/Quality:

98% ^*data from raw suppliers

7-Bromo-6-methoxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-bromo-6-methoxyIsoquinoline

There total 6 articles about 7-bromo-6-methoxyIsoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.31%

chloroformic acid ethyl ester (541-41-3) + (3-bromo-4-methoxyphenyl)-methylidene(2,2-dimethoxyethyl)amine (918492-64-5) → 7-bromo-6-methoxyisoquinoline (666735-07-5)

Guidance literature:

chloroformic acid ethyl ester; (3-bromo-4-methoxyphenyl)-methylidene(2,2-dimethoxyethyl)amine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With triethyl phosphite; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

With titanium tetrachloride; In chloroform; for 48h; Reflux;

Reference yield: 16.0%

3-bromo-4-methoxybenzylaldehyde (34841-06-0) + 2,2-dimethoxyethylamine (22483-09-6) → 7-bromo-6-methoxyisoquinoline (666735-07-5)

Guidance literature:

3-bromo-4-methoxybenzylaldehyde; 2,2-dimethoxyethylamine; With sodium sulfate; In toluene; for 6h; Reflux; Dean-Stark;

With acetyl hypochlorite; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Further stages;

Reference yield:

(3-bromo-4-methoxyphenyl)-methylidene(2,2-dimethoxyethyl)amine (918492-64-5) → 7-bromo-6-methoxyisoquinoline (666735-07-5)

Guidance literature:

(3-bromo-4-methoxyphenyl)-methylidene(2,2-dimethoxyethyl)amine; With chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With triethyl phosphite; In tetrahydrofuran; at 20 ℃; for 18h;

With ammonia; titanium tetrachloride; more than 3 stages;

upstream raw materials:

(3-bromo-4-methoxyphenyl)-methylidene(2,2-dimethoxyethyl)amine

3-bromo-4-methoxybenzylaldehyde

2,2-dimethoxyethylamine

chloroformic acid ethyl ester

Refernces

• 1、 -. "2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES". . . Retrieved 2022/01/12.
• 2、 Kwiatkowski, Jacek,Liu, Boping,Tee, Doris Hui Ying,Chen, Guoying,Ahmad, Nur Huda Binte,Wong, Yun Xuan,Poh, Zhi Ying,Ang, Shi Hua,Tan, Eldwin Sum Wai,Ong, Esther Hq,Nurul, Dinie,Poulsen, Anders,Pendharkar, Vishal,Sangthongpitag, Kanda,Lee, May Ann,Sepramaniam, Sugunavathi,Ho, Soo Yei,Cherian, Joseph,Hill, Jeffrey,Keller, Thomas H.,Hung, Alvin W.. "Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors". . p. 4386 - 4396. Retrieved 2018/05/31.