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20636-41-3

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20636-41-3 Usage

Uses

5-Hydroxy-2,4(1H,3H)-pyrimidinedione is used preparation and purification of Fluorouracil.

Check Digit Verification of cas no

The CAS Registry Mumber 20636-41-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,6,3 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20636-41:
(7*2)+(6*0)+(5*6)+(4*3)+(3*6)+(2*4)+(1*1)=83
83 % 10 = 3
So 20636-41-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H4N2O3/c7-2-1-5-4(9)6-3(2)8/h1,7H,(H2,5,6,8,9)

20636-41-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-hydroxy-1H-pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 5-hydroxypyrimidine-2,4(1H,3H)-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20636-41-3 SDS

20636-41-3Relevant articles and documents

Simple Syntheses of Isouramil and Isobarbituric Acid

Behrman

, p. 340 - 341 (1998)

Peroxodisulfate oxidations of uracil and 6-aminouracil followed by hydrolysis led to efficient syntheses of isobarbituric acid and isouramil.

Simultaneous determination of five oxidative DNA lesions in human urine

Ravanat, Jean-Luc,Guicherd, Pascale,Tuce, Zorana,Cadet, Jean

, p. 802 - 808 (2007/10/03)

A method, involving a HPLC prepurification followed by a GC/MS analysis, has been set up for the measurement of nucleic acid oxidation products in human urine. For this purpose, isotopically labeled internal standards have been prepared and used for isotope dilution mass spectrometric detection. Using this approach, four oxidized DNA bases, i.e., 5-hydroxyuracil, 5- (hydroxymethyl)uracil, 8-oxo-7,8-dihydroadenine, and 8-oxo-7,8- dihydroguanine, together with 8-oxo-7,8-dihydro-2'-deoxyguanosine have been simultaneously quantified in human urine samples. The levels of the oxidized nucleic acid constituents, as expressed in picomoles per milliliter, were determined to be, in decreasing order: 8-oxo-7,8-dihydroguanine (583 ± 376) > 5-(hydroxymethyl)uracil (121 ± 56) > 5-hydroxyuracil (58 ± 23) > 8-oxo- 7,8-dihydro-2'-deoxyguanosine (30 ± 15) > 8-oxo-7,8-dihydroadenine (7 ± 4). Attempts to determine the amount of 5,6-dihydroxy-5,6-dihydrothymine, 5- hydroxycytosine, and 2,6-diamino-4-hydroxy-5-formamidopyrimidine using the above HPLC-GC/MS method were unsuccessful.

Oxidation of nucleic acid related compounds by the peroxodisulfate ion

Itahara,Yoshitake,Koga,Nishino

, p. 2257 - 2264 (2007/10/02)

The treatment of nucleic acid bases, nucleosides, and nucleotides with peroxodisulfate ion in a phosphate buffer solution at pH 7.0 or water at 70-75°C was investigated. The reaction of thymine and 5-methylcytosine nucleosides and nucleotides resulted in the oxidation of the 5-methyl groups. The oxidation products from 1,3-dimethyluracils and the time-course of the reaction of uracils led to two plausible reaction mechanisms for the oxidation of uracils.

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