Technology Process of 4-[({4-[(2-tert-butylphenyl)amino]-2-methyl-3,4-dioxobutanoyl}oxy)amino]-5-oxo-6-(2,3,5,6-tetrafluorophenoxy)hexanoic acid
There total 18 articles about 4-[({4-[(2-tert-butylphenyl)amino]-2-methyl-3,4-dioxobutanoyl}oxy)amino]-5-oxo-6-(2,3,5,6-tetrafluorophenoxy)hexanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
water; isopropyl alcohol;
at -5 - 50 ℃;
for 46.5h;
Purification / work up;
PF-3,491,390 Form II;
- Guidance literature:
-
With
trifluoroacetic acid;
at 65 ℃;
for 2h;
Temperature;
- Guidance literature:
-
(3S)-3-[N-(N'-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-oxopentanoic acid benzyl ester;
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
under 1034.32 Torr;
In
tetrahydrofuran; n-heptane;
at -5 - 20 ℃;
for 23h;
Product distribution / selectivity;
(3S)-3-[N-(N'-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-oxopentanoic acid form II;