N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide

Base Information

Chemical Name:N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide
CAS No.:67579-25-3
Molecular Formula:C₁₆H₂₄N₂O₂
Molecular Weight:276.379
Hs Code.:
DSSTox Substance ID:DTXSID001345603,DTXSID301348301

Synonyms:SCHEMBL11461925;DTXSID001345603;DTXSID301348301;N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide;2417942-84-6;rel-N-[(1R,2R)-2-(Dimethylamino)cyclohexyl]-4-methoxybenzamide;67579-25-3

Suppliers and Price of N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:276.183778013
Heavy Atom Count:20
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1CCCCC1NC(=O)C2=CC=C(C=C2)OC
Isomeric SMILES:CN(C)[C@@H]1CCCC[C@H]1NC(=O)C2=CC=C(C=C2)OC

Technology Process of N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide

There total 5 articles about N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67198-21-4
(±)-N,N-dimethyl-trans-1,2-diaminocyclohexane

: 100-07-2
4-methoxy-benzoyl chloride

: 67579-25-3
N-((1S,2S)-2-Dimethylamino-cyclohexyl)-4-methoxy-benzamide

Guidance literature:: With triethylamine; In diethyl ether; for 17h; Ambient temperature;
DOI:10.1021/jm00150a017

Reference yield:

: 21651-78-5,15910-74-4
trans-2-(N,N-dimethylamino)cyclohexanol

: 67579-25-3
N-((1S,2S)-2-Dimethylamino-cyclohexyl)-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: (i) NaH, THF, (ii) MeSO₂Cl, (iii) /BRN= 741984/

2: perchloric acid; hydrogen / palladium on activated charcoal / ethanol / 19 h / 27002.2 Torr

3: triethylamine / diethyl ether

With perchloric acid; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol;

Reference yield:

: 4580-81-8,67198-24-7,67494-54-6
(+/-)-(trans-2-chloro-cyclohexyl)-dimethyl-amine

: 67579-25-3
N-((1S,2S)-2-Dimethylamino-cyclohexyl)-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 17 h / 95 °C

2: perchloric acid; hydrogen / palladium on activated charcoal / ethanol / 19 h / 27002.2 Torr

3: triethylamine / diethyl ether

With perchloric acid; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol;