N-Cyclohexylmethacrylamide

Base Information

• Chemical Name: N-Cyclohexylmethacrylamide
• CAS No.: 2918-67-4
• Molecular Formula: C10H17 N O
• Molecular Weight: 167.251
• Hs Code.: 2924299090
• European Community (EC) Number: 220-853-4
• DSSTox Substance ID: DTXSID50951775
• Nikkaji Number: J306.846C
• Wikidata: Q82930202
• Mol file: 2918-67-4.mol

Synonyms:N-Cyclohexylmethacrylamide;2918-67-4;N-cyclohexyl methacrylamide;N-cyclohexyl-2-methylprop-2-enamide;CYCLOHEXYL METHACRYLAMIDE;EINECS 220-853-4;2-Propenamide, N-cyclohexyl-2-methyl-;SCHEMBL184537;DTXSID50951775;MFCD00078432;AKOS005207093;N-Cyclohexyl-2-methylprop-2-enimidic acid;FT-0634550;A819801

Chemical Property of N-Cyclohexylmethacrylamide

Chemical Property:

• Vapor Pressure: 0.000345mmHg at 25°C
• Boiling Point: 319.2°Cat760mmHg
• Flash Point: 187.6°C
• PSA: 29.10000
• Density: 0.95g/cm³
• LogP: 2.40230
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 167.131014166
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

98%min ^*data from raw suppliers

Cyclohexylmethacrylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)NC1CCCCC1

Technology Process of N-Cyclohexylmethacrylamide

There total 10 articles about N-Cyclohexylmethacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

cyclohexylamine (108-91-8,157973-60-9) + Methacryloyl chloride (920-46-7,26937-45-1) → N-cyclohexyl methacrylamide (2918-67-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c2cc36137j

Reference yield: 50.0%

poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexyl methacrylamide (2918-67-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Inert atmosphere;

DOI:10.1021/ol201900d

Reference yield: 20.0%

2-bromo-2-methyl-N-cyclohexylpropanamide (110228-40-5) + 1-cyclopentylpiperazine (21043-40-3) → 2-(cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one (1353848-11-9) + N-cyclohexyl methacrylamide (2918-67-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 70 ℃; for 18h;

DOI:10.1080/00397911.2011.629357

upstream raw materials:

1,2-propanediene

carbon monoxide

cyclohexylamine

poly(methacrylic acid)

Downstream raw materials:

potassium N-cyclohexyl-2-methyl-3-(trifluoroborato)propanamide

(Z)-N-[3-(cyclohexylamino)-2-methyl-3-oxoprop-1-enyl]-4-nitrobenzamide

(2E,4Z)-n-butyl 6-cyclohexylamino-5-methyl-6-oxohexa-2,4-dienoate

1-cyclohexyl-3-methyl-5,6-diphenylpyridin-2(1H)-one

Refernces

• 1、 Kelly, Nicholas M.,Wellejus, Anja,Elbrond-Bek, Heidi,Weidner, Morten Sloth,Jorgensen, Signe Humle. "Favorskii-like rearrangement of an aliphatic α-halo amide". . p. 1243 - 1249. Retrieved 2013/04/10.
• 2、 Zhang, Jian,Loh, Teck-Peng. "Ruthenium- and rhodium-catalyzed cross-coupling reaction of acrylamides with alkenes: Efficient access to (Z,E)-dienamides". supporting information. p. 11232 - 11234. Retrieved 2013/01/15.