Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl-

Base Information

• Chemical Name: Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl-
• CAS No.: 71171-94-3
• Molecular Formula: C11H12 F N O
• Molecular Weight: 193.221
• Mol file: 71171-94-3.mol

Synonyms:2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole;2-(p-Fluorophenyl)-4,4-dimethyloxazoline

Chemical Property of Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl-

Chemical Property:

• Vapor Pressure: 0.0227mmHg at 25°C
• Boiling Point: 258°C at 760 mmHg
• Flash Point: 109.9°C
• PSA: 21.59000
• Density: 1.13g/cm³
• LogP: 1.81670

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl-

There total 12 articles about Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-fluoro-benzoylamino)-2-methyl-propan-1-ol (343316-37-0) → 2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-oxazole (71171-94-3)

Guidance literature:

With thionyl chloride; at 20 ℃; for 0.25h;

Reference yield: 94.0%

4-fluorobenzaldehyde (459-57-4) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-oxazole (71171-94-3)

Guidance literature:

4-fluorobenzaldehyde; 2-Amino-2-methyl-1-propanol; In dichloromethane; at 25 ℃; for 20h; Inert atmosphere; Schlenk technique; Molecular sieve;

With N-Bromosuccinimide; In dichloromethane; at 25 ℃; for 4h; Inert atmosphere; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.orglett.9b01350

Reference yield: 92.0%

4-fluorobenzoyl chloride (403-43-0) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-oxazole (71171-94-3)

Guidance literature:

With potassium carbonate; In water; toluene; at 10 - 20 ℃; for 2h;

upstream raw materials:

2-(4-fluoro-benzoylamino)-2-methyl-propan-1-ol

4,4-dimethyl-2-oxazoline

1-Bromo-4-fluorobenzene

Li(4,4-dimethyl-2-oxazolinyl)

Downstream raw materials:

2-[4-fluoro-2-(2-methylallyl)phenyl]-4,4-dimethyl-1,3-oxazoline

4-fluoro-2-(2-methylallyl)benzaldehyde

C₂₀H₁₉FN₂

2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

Refernces

• 1、 G?bel, Dominik,Clamor, Nils,Lork, Enno,Nachtsheim, Boris J.. "Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores". supporting information. p. 5373 - 5377. Retrieved 2019/06/07.
• 2、 Batista, Joo H. C.,Santos, Fernanda M. Dos,Bozzini, Leandro A.,Vessecchi, Ricardo,Oliveira, Alfredo R. M.,Clososki, Giuliano C.. "Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl". . p. 967 - 977. Retrieved 2015/02/19.