2-(2-Phenoxyethoxy)ethanamine

Base Information

• Chemical Name: 2-(2-Phenoxyethoxy)ethanamine
• CAS No.: 6338-54-1
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.235
• NSC Number: 40759
• DSSTox Substance ID: DTXSID60285159
• Wikidata: Q82020432
• Mol file: 6338-54-1.mol

Synonyms:2-(2-phenoxyethoxy)ethanamine;2-(2-phenoxyethoxy)ethan-1-amine;6338-54-1;NSC40759;SCHEMBL8555021;DTXSID60285159;NSC 40759;NSC-40759;AKOS000158224;EN300-58318;AB01006775-01

Chemical Property of 2-(2-Phenoxyethoxy)ethanamine

Chemical Property:

• Vapor Pressure: 0.0014mmHg at 25°C
• Boiling Point: 296.9°C at 760 mmHg
• Flash Point: 145.2°C
• Density: 1.047g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 114

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCCOCCN

Technology Process of 2-(2-Phenoxyethoxy)ethanamine

There total 4 articles about 2-(2-Phenoxyethoxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-phenoxyethoxy)ethanol (104-68-7,9004-78-8) → 2-(2-phenoxyethoxy)ethanamine (6338-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / Inert atmosphere; Reflux

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; ethanol; 1: Mitsunobu reaction;

DOI:10.1021/jm300689c

Reference yield:

N-[2-(2-phenoxy-ethoxy)-ethyl]-phthalimide (6594-70-3) → 2-(2-phenoxyethoxy)ethanamine (6338-54-1)

Guidance literature:

With hydrazine hydrate; In ethanol; Inert atmosphere; Reflux;

DOI:10.1021/jm300689c

Reference yield:

2-(2-phenoxyethoxy)ethyl chloride (2243-44-9) → 2-(2-phenoxyethoxy)ethanamine (6338-54-1)

Guidance literature:

Multistep reaction; (i) phthalimide , (ii) N2H4*H2O;

upstream raw materials:

2-(2-phenoxyethoxy)ethyl chloride

N-[2-(2-phenoxy-ethoxy)-ethyl]-phthalimide

2-(2-phenoxyethoxy)ethanol

Downstream raw materials:

tris-(5-phenoxy-3-oxapentyl)amine

2-(2-phenoxyethoxy)ethanisocyanate

(3-(3-carbamoyl-1H-pyrrol-1-yl)phenoxycarbonyl)(2-(2-phenoxyethoxy)ethyl)amine

Refernces