Sulfamic acid, dimethyl-, 7-[(4-fluorophenyl)methyl]-7,8-dihydro-6-methylene-8-oxo-9-[[tris(1-meth ylethyl)silyl]oxy]-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Base Information

Chemical Name:Sulfamic acid, dimethyl-, 7-[(4-fluorophenyl)methyl]-7,8-dihydro-6-methylene-8-oxo-9-[[tris(1-meth ylethyl)silyl]oxy]-6H-pyrrolo[3,4-g]quinolin-5-yl ester
CAS No.:684286-52-0
Molecular Formula:C30H38FN3O5SSi
Molecular Weight:599.799
Hs Code.:

Sulfamic acid, dimethyl-,
7-[(4-fluorophenyl)methyl]-7,8-dihydro-6-methylene-8-oxo-9-[[tris(1-meth
ylethyl)silyl]oxy]-6H-pyrrolo[3,4-g]quinolin-5-yl ester

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Chemical Property of Sulfamic acid, dimethyl-, 7-[(4-fluorophenyl)methyl]-7,8-dihydro-6-methylene-8-oxo-9-[[tris(1-meth ylethyl)silyl]oxy]-6H-pyrrolo[3,4-g]quinolin-5-yl ester

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Technology Process of Sulfamic acid, dimethyl-, 7-[(4-fluorophenyl)methyl]-7,8-dihydro-6-methylene-8-oxo-9-[[tris(1-meth ylethyl)silyl]oxy]-6H-pyrrolo[3,4-g]quinolin-5-yl ester

There total 5 articles about Sulfamic acid, dimethyl-, 7-[(4-fluorophenyl)methyl]-7,8-dihydro-6-methylene-8-oxo-9-[[tris(1-meth ylethyl)silyl]oxy]-6H-pyrrolo[3,4-g]quinolin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 684285-24-3
dimethylsulfamic acid 7-(4-fluoro-benzyl)-6,8-dioxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

: 684286-52-0
dimethylsulfamic acid 7-(4-fluoro-benzyl)-6-methylene-8-oxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Guidance literature:: dimethylsulfamic acid 7-(4-fluoro-benzyl)-6,8-dioxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester; With methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In dichloromethane; water; for 30h;

Reference yield: 87.0%

: 684285-24-3
dimethylsulfamic acid 7-(4-fluoro-benzyl)-6,8-dioxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

: 75-16-1
methylmagnesium bromide

: 684286-52-0
dimethylsulfamic acid 7-(4-fluoro-benzyl)-6-methylene-8-oxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Guidance literature:: dimethylsulfamic acid 7-(4-fluoro-benzyl)-6,8-dioxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester; methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In dichloromethane; for 0.5h;
DOI:10.1016/j.bmcl.2006.05.008

Reference yield:

: 684284-29-5
7-(4-fluoro-benzyl)-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

: 684286-52-0
dimethylsulfamic acid 7-(4-fluoro-benzyl)-6-methylene-8-oxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 36 h

2.1: 75 percent / DMAP; TEA / CH₂Cl₂ / 2 h / 20 °C

3.1: tetrahydrofuran / 1 h / 20 °C

3.2: 87 percent / aq. HCl / CH₂Cl₂ / 0.5 h

With 1H-imidazole; dmap; TEA; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.008