Benzenemethanol, a-ethyl-4-hydroxy-3-methoxy-

Base Information

• Chemical Name: Benzenemethanol, a-ethyl-4-hydroxy-3-methoxy-
• CAS No.: 6997-34-8
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• Mol file: 6997-34-8.mol

Synonyms:

Chemical Property of Benzenemethanol, a-ethyl-4-hydroxy-3-methoxy-

Chemical Property:

• Vapor Pressure: 0.000191mmHg at 25°C
• Melting Point: 86 °C
• Boiling Point: 314.9±32.0 °C(Predicted)
• PKA: 10.25±0.31(Predicted)
• PSA: 49.69000
• Density: 1.142±0.06 g/cm3(Predicted)
• LogP: 1.84420

Purity/Quality:

95% ^*data from raw suppliers

4-(1-Hydroxypropyl)-2-methoxyphenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-ethyl-4-hydroxy-3-methoxy-

There total 5 articles about Benzenemethanol, a-ethyl-4-hydroxy-3-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.3%

ethylmagnesium bromide (925-90-6) + vanillin (121-33-5,8014-42-4) → 1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (6997-34-8)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 2.25h; Inert atmosphere; Cooling with ice;

DOI:10.1002/jlcr.3329

Reference yield:

2-methoxy-4-n-propylphenol (2785-87-7) → 2-methoxy-4-propenylphenol (97-54-1) + 1-(4'-hydroxy-3'-methoxyphenyl)propan-1-one (1835-14-9) + 1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (6997-34-8)

Guidance literature:

With 4-ethylphenol oxidase from Gulosibacter chungangensis; In aq. phosphate buffer; dimethyl sulfoxide; at 25 ℃; for 24h; pH=8; Enzymatic reaction;

DOI:10.1002/cbic.202100457

Reference yield:

1-(4-acetoxy-3-methoxy-phenyl)-propan-1-one (22263-18-9) → 1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (6997-34-8)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1246/bcsj.29.265

upstream raw materials:

1-(4-acetoxy-3-methoxy-phenyl)-propan-1-one

ethylmagnesium bromide

vanillin

ethylmagnesium iodide

Downstream raw materials:

[1,4]benzoquinone-mono-(4-hydroxy-3-methoxy-phenylimine)

1-(4'-hydroxy-3'-methoxyphenyl)propan-1-one

1-(4-hydroxy-3-methoxy-phenyl)-propane-1-sulfonic acid ; barium salt

benzene-1,2-diol

Refernces

• 1、 Alvigini, Laura,Fraaije, Marco W.,Gran-Scheuch, Alejandro,Guo, Yiming,Mattevi, Andrea,Saifuddin, Mohammad,Trajkovic, Milos. "Discovery, Biocatalytic Exploration and Structural Analysis of a 4-Ethylphenol Oxidase from Gulosibacter chungangensis". . p. 3225 - 3233. Retrieved 2021/10/04.
• 2、 Angle, Steven R.,Arnaiz, Damian O.. "Formal Cycloaddition of Benzylic Cations with Alkenes". . p. 5937 - 5947. Retrieved 2007/10/02.