2-(4-Fluoro-3-methylphenyl)-1H-indole

Base Information

• Chemical Name: 2-(4-Fluoro-3-methylphenyl)-1H-indole
• CAS No.: 70059-35-7
• Molecular Formula: C15H12FN
• Molecular Weight: 225.265
• DSSTox Substance ID: DTXSID70505310
• Wikidata: Q82360323
• Mol file: 70059-35-7.mol

Synonyms:2-(4-Fluoro-3-methylphenyl)-1H-indole;70059-35-7;DTXSID70505310

Chemical Property of 2-(4-Fluoro-3-methylphenyl)-1H-indole

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 225.095377549
• Heavy Atom Count: 17
• Complexity: 268

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)C2=CC3=CC=CC=C3N2)F

Technology Process of 2-(4-Fluoro-3-methylphenyl)-1H-indole

There total 3 articles about 2-(4-Fluoro-3-methylphenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-[1-(4-Fluoro-3-methyl-phenyl)-eth-(E)-ylidene]-N'-phenyl-hydrazine → 2-(4-Fluoro-3-methyl-phenyl)-1H-indole (70059-35-7)

Guidance literature:

With PPA;

DOI:10.1007/BF00903661

Reference yield:

C15H12FN → 2-(4-Fluoro-3-methyl-phenyl)-1H-indole (70059-35-7)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl acetamide; at 180 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1055/s-0028-1083624

Reference yield:

1-(4-fluoro-3-methylphenyl)ethanone (369-32-4) + phenylhydrazine (100-63-0) → 2-(4-Fluoro-3-methyl-phenyl)-1H-indole (70059-35-7)

Guidance literature:

With 2.) P_.P_.A_.; Multistep reaction; 2.) 125-150 deg C;

DOI:10.1016/S0022-1139(00)83024-9

upstream raw materials:

1-(4-fluoro-3-methylphenyl)ethanone

phenylhydrazine

Downstream raw materials:

2-(4-Fluoro-3-methyl-phenyl)-3-piperidin-1-ylmethyl-1H-indole

2-(4-Fluoro-3-methyl-phenyl)-3-morpholin-4-ylmethyl-1H-indole

1-[2-(4-Fluoro-3-methyl-phenyl)-1H-indol-3-yl]-ethanone

[2-(4-Fluoro-3-methyl-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine