1-[(2-Hydroxybenzoyl)oxy]pyrrolidine-2,5-dione

Base Information

• Chemical Name: 1-[(2-Hydroxybenzoyl)oxy]pyrrolidine-2,5-dione
• CAS No.: 70120-40-0
• Molecular Formula: C11H9NO5
• Molecular Weight: 235.196
• DSSTox Substance ID: DTXSID90579210
• Wikidata: Q82469664
• Mol file: 70120-40-0.mol

Synonyms:70120-40-0;1-[(2-Hydroxybenzoyl)oxy]pyrrolidine-2,5-dione;SCHEMBL8540066;DTXSID90579210;(2,5-dioxopyrrolidin-1-yl) 2-hydroxybenzoate

Chemical Property of 1-[(2-Hydroxybenzoyl)oxy]pyrrolidine-2,5-dione

Chemical Property:

• Boiling Point: 397.9±44.0 °C(Predicted)
• PKA: 7.40±0.30(Predicted)
• PSA: 83.91000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 0.55090
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 235.04807239
• Heavy Atom Count: 17
• Complexity: 338

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)OC(=O)C2=CC=CC=C2O

Technology Process of 1-[(2-Hydroxybenzoyl)oxy]pyrrolidine-2,5-dione

There total 2 articles about 1-[(2-Hydroxybenzoyl)oxy]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → salicylic?acid?succinimidyl ester (70120-40-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.3987/COM-92-S(T)88

Reference yield:

→ salicylic?acid?succinimidyl ester (70120-40-0)

Guidance literature:

Salicylsaeure, N-Hydroxysuccinimid;

Reference yield: 83.0%

salicylic?acid?succinimidyl ester (70120-40-0) + glycine ethyl ester hydrochloride (623-33-6) → ethyl N-salicyloylaminoacetate (5853-89-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 1.5h;

DOI:10.3987/COM-92-S(T)88

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

salicylic acid

Downstream raw materials:

ethyl N-salicyloylaminoacetate

salicylic acid 4-nitrobenzyl ester

p-methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-(2-hydroxybenzamido)-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2-6)-β-D-galactopyranoside

C₁₇H₂₃N₂O₁₀P₂⁽¹⁺⁾

Refernces

• 1、 -. "IMMEDIATE-RELEASE ABUSE DETERRENT COMPOSITIONS OR MEDICAMENTS FOR TREATING PAIN, ADD, ADHD AND OTHER SYNDROMES OR DISORDERS". Sheet 5. . Retrieved 2018/04/27.
• 2、 Zhou, Li-Sheng,Yang, Ke-Wu,Feng, Lei,Xiao, Jian-Min,Liu, Cheng-Cheng,Zhang, Yi-Lin,Crowder, Michael W.. "Novel fluorescent risedronates: Synthesis, photodynamic inactivation and imaging of Bacillus subtilis". supporting information. p. 949 - 954. Retrieved 2013/03/14.