6-[3-(benzyloxy)phenyl]-2-(4-morpholinyl)-4(3H)-pyrimidinone

Base Information

• Chemical Name: 6-[3-(benzyloxy)phenyl]-2-(4-morpholinyl)-4(3H)-pyrimidinone
• CAS No.: 701244-25-9
• Molecular Formula: C21H21N3O3
• Molecular Weight: 363.416
• Mol file: 701244-25-9.mol

Synonyms:2-morpholin-4-yl-6-[3-(phenylmethoxy)phenyl]-3-hydropyrimidin-4-one;

Chemical Property of 6-[3-(benzyloxy)phenyl]-2-(4-morpholinyl)-4(3H)-pyrimidinone

Chemical Property:

• PSA: 67.45000
• LogP: 2.91750

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 6-[3-(benzyloxy)phenyl]-2-(4-morpholinyl)-4(3H)-pyrimidinone

There total 1 articles about 6-[3-(benzyloxy)phenyl]-2-(4-morpholinyl)-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 3-(3-benzyloxyphenyl)-3-oxopropanoate (73083-19-9) + Morpholine-4-carboxamidine; hydrobromide (157415-17-3) → 6-(3-benzyloxyphenyl)-2-(morpholin-4-yl)pyrimidin-4(3H)-one (701244-25-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 115 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.10.021

Reference yield: 99.0%

6-(3-benzyloxyphenyl)-2-(morpholin-4-yl)pyrimidin-4(3H)-one (701244-25-9) + phenyl trifluoromethanesulfonamide (456-64-4) → 6-(3-benzyloxyphenyl)-2-(morpholin-4-yl)pyrimidin-4-yl trifluoromethanesulfonate (701244-26-0)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 ℃;

Reference yield: 99.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 6-(3-benzyloxyphenyl)-2-(morpholin-4-yl)pyrimidin-4(3H)-one (701244-25-9) → 6-(3-benzyloxyphenyl)-2-(morpholin-4-yl)pyrimidin-4-yl trifluoromethanesulfonate (701244-26-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.10.021

upstream raw materials:

ethyl 3-(3-benzyloxyphenyl)-3-oxopropanoate

Morpholine-4-carboxamidine; hydrobromide

Downstream raw materials:

6-(3-benzyloxyphenyl)-2-(morpholin-4-yl)pyrimidin-4-yl trifluoromethanesulfonate

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