Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-, ethyl ester, (1R,2R)-rel-

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-, ethyl ester, (1R,2R)-rel-
• CAS No.: 70461-58-4
• Molecular Formula: C₁₂H₁₃FO₂
• Molecular Weight: 208.232
• Mol file: 70461-58-4.mol

Synonyms:cis-(+/-)-2-(4-fluoro-phenyl)-cyclopropanecarboxylic acid ethyl ester;TRANS-2-(4-FLUOROPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER;ethyl 2-(4-fluorophenyl)-cyclopropanecarboxylate;

Chemical Property of Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-, ethyl ester, (1R,2R)-rel-

Chemical Property:

• Boiling Point: 265.6±33.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.184±0.06 g/cm3(Predicted)
• LogP: 2.49230

Purity/Quality:

97% ^*data from raw suppliers

trans-2-(4-Fluoro-phenyl)-cyclopropanecarboxylicacidethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-, ethyl ester, (1R,2R)-rel-

There total 9 articles about Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-, ethyl ester, (1R,2R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

diazoacetic acid ethyl ester (623-73-4) + para-fluorostyrene (405-99-2) → trans-2-(4-fluorophenyl)cyclopropane carboxylic acid ethyl ester (70461-58-4,70461-60-8)

Guidance literature:

dirhodium tetraacetate; In toluene; at 80 - 85 ℃; for 1.5h;

DOI:10.1016/j.bmc.2006.10.002

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + para-fluorostyrene (405-99-2) → cis-2-(4-fluorophenyl)cyclopropanecarboxylic acid ethyl ester (70461-58-4,70461-60-8) + trans-2-(4-fluorophenyl)cyclopropane carboxylic acid ethyl ester (70461-58-4,70461-60-8) + Diethyl maleate (141-05-9)

Guidance literature:

With μ-oxo-diiron octapropylporphyrazine; In toluene; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.9b02718

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + para-fluorostyrene (405-99-2) → cis-2-(4-fluorophenyl)cyclopropanecarboxylic acid ethyl ester (70461-58-4,70461-60-8) + trans-2-(4-fluorophenyl)cyclopropane carboxylic acid ethyl ester (70461-58-4,70461-60-8) + Diethyl maleate (141-05-9)

Guidance literature:

With μ-oxo-diiron octapropylporphyrazine; In toluene; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.9b02718

upstream raw materials:

diazoacetic acid ethyl ester

para-fluorostyrene

ethyl rac-(1S,2S)-2-phenylcycloproanecarboxylate

ethyl 4-fluorocinnamate

Downstream raw materials:

trans-2-(4-fluorophenyl)cyclopropane-1-carbaldehyde

(±)-trans-2-(4-fluorophenyl)cyclopropane-1-carboxylic acid