2-Propenoic acid, 3-(2-methylphenyl)-, methyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 3-(2-methylphenyl)-, methyl ester
• CAS No.: 70625-62-6
• Molecular Formula: C11H12O2
• Molecular Weight: 176.21200
• Mol file: 70625-62-6.mol

Synonyms:Butyl-(2,2-diaethoxy-aethyl)-nitroso-amin;N-Nitroso-butylaminoacetal;

Chemical Property of 2-Propenoic acid, 3-(2-methylphenyl)-, methyl ester

Chemical Property:

• Boiling Point: 267.0±9.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.057±0.06 g/cm3(Predicted)
• LogP: 2.18120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(2-methylphenyl)-, methyl ester

There total 47 articles about 2-Propenoic acid, 3-(2-methylphenyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trimethyl phosphonoacetate (5927-18-4) + 2-methylphenyl aldehyde (529-20-4) → methyl (E)-3-(2-methylphenyl)-2-propenoate (70625-62-6,75950-75-3,130451-86-4)

Guidance literature:

trimethyl phosphonoacetate; With sodium hydride; In tetrahydrofuran; paraffin oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

2-methylphenyl aldehyde; In tetrahydrofuran; paraffin oil; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.202100026

Reference yield: 99.0%

ortho-methylphenyl iodide (615-37-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (E)-3-(2-methylphenyl)-2-propenoate (70625-62-6,75950-75-3,130451-86-4)

Guidance literature:

With trihexyl(tetradecyl)phosphonium chloride; sodium acetate; palladium diacetate; In water; at 50 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.08.103

Reference yield: 98.0%

methanol (67-56-1) + 3-(2-methylphenyl)prop-2-en-1-al (93614-78-9,4549-82-0) → 3-(2-methylphenyl)acrylic acid methyl ester (75950-75-3,130451-86-4,70625-62-6)

Guidance literature:

With 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; C₂₃H₁₉Cl₃N₃⁽¹⁺⁾*Cl^(1-); benzoic acid; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1002/anie.202104712

upstream raw materials:

2-methyl phenylmethylene propanedionic acid dimethyl ether

ortho-methylphenyl iodide

4-iodoanisol

acrylic acid methyl ester

Downstream raw materials:

(E)-3-(2-methylphenyl)acrylic acid

(E)-3-(2-methylphenyl)-2-propenol

methyl (E)-3-(2’-(bromomethyl)phenyl)acrylate

o,o'-Dimethyl-β-truxillsaeuredimethylester