N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide

Base Information

Chemical Name:N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide
CAS No.:708285-68-1
Molecular Formula:C12H15N3O3
Molecular Weight:249.269
Hs Code.:
DSSTox Substance ID:DTXSID60387985
Wikidata:Q27185464
ChEMBL ID:CHEMBL1451919

Synonyms:708285-68-1;N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide;N-(4-nitrophenyl)-2-pyrrolidin-1-ylacetamide;HMS2665M21;1-Pyrrolidineacetamide, N-(4-nitrophenyl)-;MLS000665035;SCHEMBL4750163;CHEMBL1451919;DTXSID60387985;CHEBI:107245;STL089707;AKOS000369109;SMR000294738;N-(4-nitrophenyl)-2-(pyrrolidin-1-yl)acetamide;SR-01000280576;SR-01000280576-1;Q27185464;Z46169235

Suppliers and Price of N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:249.11134135
Heavy Atom Count:18
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)CC(=O)NC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide

There total 4 articles about N-(4-nitrophenyl)-2-(1-pyrrolidinyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 123-75-1
pyrrolidine

: 17329-87-2
2-chloro-N-(4-nitro-phenyl)-acetamide

: 708285-68-1
N-(4-nitro-phenyl)-2-(pyrrolidin-1-yl)-acetamide

Guidance literature:: In tetrahydrofuran; at 50 ℃;
DOI:10.1016/j.ejmech.2014.02.018

Reference yield: 91.0%

: 123-75-1
pyrrolidine

: 100-01-6,104810-17-5
4-nitro-aniline

: 79-04-9
chloroacetyl chloride

: 708285-68-1
N-(4-nitro-phenyl)-2-(pyrrolidin-1-yl)-acetamide

Guidance literature:: 4-nitro-aniline; chloroacetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2.3h; Cooling with ice;

pyrrolidine; In tetrahydrofuran; at 20 ℃; for 14h; Cooling with ice;
DOI:10.1039/c0cc02917c

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 708285-68-1
N-(4-nitro-phenyl)-2-(pyrrolidin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / tetrahydrofuran / -15 - 20 °C

2: 82 percent / methanol / 0 - 20 °C

With triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ja0661919