1-Piperidinecarboxylic acid, 4-(3-chlorophenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-(3-chlorophenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester
CAS No.:716358-39-3
Molecular Formula:C18H24ClNO3
Molecular Weight:337.846
Hs Code.:

Synonyms:4-(3-Chloro-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-(3-chlorophenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 4-(3-chlorophenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester

Chemical Property:

PSA：46.61000
LogP:4.13560

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 1-Piperidinecarboxylic acid, 4-(3-chlorophenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester

There total 7 articles about 1-Piperidinecarboxylic acid, 4-(3-chlorophenyl)-4-(2-oxoethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 716358-38-2
tert-butyl 4-(3-chlorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

: 716358-39-3
tert-butyl 4-(3-chlorophenyl)-4-(2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -40 ℃; for 1h;
DOI:10.1080/00397910500374971

Reference yield: 66.0%

: 716358-38-2
tert-butyl 4-(3-chlorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate

: 77-92-9,906507-37-7
citric acid

: 716358-39-3
tert-butyl 4-(3-chlorophenyl)-4-(2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-(3-chlorophenyl)-4-(cyanomethyl)piperidine-1-carboxylate; With diisobutylaluminium hydride; In dichloromethane; at -35 - -30 ℃; for 0.5h;

citric acid; In methanol; dichloromethane;

Reference yield:

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 716358-39-3
tert-butyl 4-(3-chlorophenyl)-4-(2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 20 °C

1.2: 75 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C

2.1: sodium hydroxide / ethanol; H₂O / 6.5 h / 20 °C

3.1: copper(I) oxide / acetonitrile / 0.5 h / Heating

4.1: 66 percent / DIBAL-H / CH₂Cl₂ / 1 h / -40 °C

With copper(I) oxide; sodium hydroxide; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 1.2: Grignard addition;
DOI:10.1080/00397910500374971