[1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

Base Information

Chemical Name:[1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid
CAS No.:716358-37-1
Molecular Formula:C₁₉H₂₃ClN₂O₄
Molecular Weight:378.856
Hs Code.:

Synonyms:[1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

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Chemical Property of [1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

Chemical Property:

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Technology Process of [1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

There total 4 articles about [1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 644982-76-3
tert-butyl 4-(3-chlorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

: 716358-37-1
[1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

Guidance literature:: With sodium hydroxide; ethanol; water; at 20 ℃; for 6.5h;
DOI:10.1021/jm800598a

Reference yield:

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 716358-37-1
[1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 20 °C

1.2: 75 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C

2.1: sodium hydroxide / ethanol; H₂O / 6.5 h / 20 °C

With sodium hydroxide; magnesium; In tetrahydrofuran; ethanol; water; 1.2: Grignard addition;
DOI:10.1080/00397910500374971

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 716358-37-1
[1-(tert-butoxycarbonyl)-4-(3-chlorophenyl)piperidin-4-yl](cyano)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / NH₄OAc; AcOH; benzene

2.1: magnesium / tetrahydrofuran / 20 °C

2.2: 75 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydroxide / ethanol; H₂O / 6.5 h / 20 °C

With sodium hydroxide; ammonium acetate; magnesium; acetic acid; benzene; In tetrahydrofuran; ethanol; water; 2.2: Grignard addition;
DOI:10.1080/00397910500374971