4-Methyl-N,N'-m-phenylenediformamide

Base Information

• Chemical Name: 4-Methyl-N,N'-m-phenylenediformamide
• CAS No.: 6262-23-3
• Molecular Formula: C9H10N2O2
• Molecular Weight: 178.191
• European Community (EC) Number: 228-414-9
• NSC Number: 8623
• DSSTox Substance ID: DTXSID90978183
• Nikkaji Number: J211.488G
• Wikidata: Q82963517
• Mol file: 6262-23-3.mol

Synonyms:4-Methyl-N,N'-m-phenylenediformamide;6262-23-3;N-(3-formamido-4-methylphenyl)formamide;EINECS 228-414-9;NSC8623;N,4-tolylenediamine;N,4-Tolylenebisformamide;SCHEMBL9597648;Formamide,N'-2,4-tolylenebis-;DTXSID90978183;NSC 8623;NSC-8623;Formamide,N'-(4-methyl-m-phenylene)bis-;N,N'-(4-methyl-1,3-phenylene)diformamide;(4-Methyl-1,3-phenylene)dimethanimidic acid;Formamide,N'-(4-methyl-1,3-phenylene)bis-;N,N'-(4-Methyl-1,3-phenylene)bisformamide;Formamide, N,N'-(4-methyl-m-phenylene)bis-;Formamide, N,N'-(4-methyl-1,3-phenylene)bis-

Chemical Property of 4-Methyl-N,N'-m-phenylenediformamide

Chemical Property:

• Boiling Point: 476.5°Cat760mmHg
• Flash Point: 223.7°C
• PSA: 58.20000
• Density: 1.279g/cm³
• LogP: 2.54940
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 178.074227566
• Heavy Atom Count: 13
• Complexity: 185

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)NC=O)NC=O

Technology Process of 4-Methyl-N,N'-m-phenylenediformamide

There total 7 articles about 4-Methyl-N,N'-m-phenylenediformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formic acid (64-18-6) + 4-methylbenzene-1,3-diamine (95-80-7,71111-07-4) → N,N'-(4-methyl-1,3-phenylene)diformamide (6262-23-3)

Guidance literature:

With Co₃O₄ nanoparticles; at 40 ℃; for 0.2h; Green chemistry;

DOI:10.1007/s11164-016-2631-7

Reference yield: 51.0%

Methyl formate (107-31-3) + 4-methylbenzene-1,3-diamine (95-80-7,71111-07-4) → N,N'-(4-methyl-1,3-phenylene)diformamide (6262-23-3)

Guidance literature:

With sodium methylate; In methanol; at 50 ℃; for 72h; Green chemistry;

DOI:10.1039/d0gc02412k

Reference yield: 18.0%

Methyl formate (107-31-3) + N-(3-amino-4-methylphenyl)formamide (854701-62-5) → 2,4-bis(methoxycarbonylamino)toluene (6935-99-5) + N,N'-(4-methyl-1,3-phenylene)diformamide (6262-23-3) + methyl (5-formamido-2-methylphenyl)carbamate

Guidance literature:

Methyl formate; With palladium 10% on activated carbon; oxygen; sodium methylate; sodium iodide; In methanol; at 140 ℃; Green chemistry;

N-(3-amino-4-methylphenyl)formamide; In methanol; at 140 ℃; for 4h; Autoclave; Green chemistry;

DOI:10.1039/d0gc02412k

upstream raw materials:

formic acid

4-methylbenzene-1,3-diamine

2,4-dinitrotoluene

2,6-dinitrotoluene