142733-60-6

Basic information

• Product Name: diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate
• Synonyms: diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate;diethyl 7-phenyl-6,8-dioxaspiro[3.5]none-2,2-dicarboxylate;2,2-Diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate
• CAS NO: 142733-60-6
• Molecular Formula: C₁₉H₂₄O₆
• Molecular Weight: 348.39026
• Product Categories: Heterocycle-other series
• Mol File: 142733-60-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 436.3 °C at 760 mmHg
• Flash Point: 189.6 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 8.21E-08mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• CAS DataBase Reference: diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate(142733-60-6)
• EPA Substance Registry System: diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate(142733-60-6)

Safety Data

• Hazardous Substances Data: 142733-60-6(Hazardous Substances Data)

Usage

General Description

Diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate is a complex organic compound with a molecular structure composed of two ester groups and a spirocyclic ring system. It is commonly used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. The compound has been found to exhibit potential antioxidant and anti-inflammatory properties, making it of interest for potential therapeutic applications. Its unique structure and chemical properties make it a valuable building block for the creation of new drug molecules and can be employed in the development of novel pharmaceutical products. Additionally, its versatile nature allows for it to be used in the design and synthesis of various other functional organic materials. Overall, diethyl 7-phenyl-6,8-dioxaspiro[3.5]nonane-2,2-dicarboxylate is a versatile and important chemical compound with a wide range of potential uses in the fields of pharmaceuticals and materials science.

InChI:InChI=1/C19H24O6/c1-3-22-16(20)19(17(21)23-4-2)10-18(11-19)12-24-15(25-13-18)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3

Upstream product

• 100-52-7 benzaldehyde 
• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 
• 3733-29-7 5,5‐bis(bromomethyl)‐2‐phenyl‐1,3‐dioxane 
• 105-53-3 diethyl malonate 
• 2209-89-4 (2-phenyl-1,3-dioxane-5,5-diyl)di(methylene) bis(4-methylbenzenesulfonate) 
• 2425-41-4 5,5-dihydroxymethyl-2-phenyl-1,3-dioxane 

Downstream Products

• 142733-62-8 cis-methyl 3-carboxamidocyclobutanecarboxylate 
• 7439-33-0 trans-cyclobutane-1,3-dicarboxylic acid 
• 2398-16-5 cis-1,3-cyclobutane dicarboxylic acid 
• 142733-61-7 cis-1,3-cyclobutanedicarboxylic acid monomethyl ester 
• 4462-97-9 cis-cyclobutane-1,3-dicarboxylic acid anhydride 
• 77614-64-3 7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylic acid 

Relevant articles and documents

Nitroxide derivative of ROCK kinase inhibitor

The invention provides a small molecular compound of a NO donor. The small molecular compound is characterized in that the small molecular compound is a compound shown represented by structural formula I shown in the description, or a stereoisomer, a geometrical isomer, a tautomer, a racemate, a deuterated isotope derivative, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof; and in the formula I, ring A is a substituted or unsubstituted heteroaromatic ring, X is selected from (CH2)n, n is selected from 0, 1, 2 and 3, R is a substituent group of terminal -O-NO2, R is selected from hydrogen, a hydroxyl group, halogen, an amino group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group and a substituted or unsubstituted heteroalkyl group, and R and R are respectively and independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted naphthenic base or an amino protecting group, or R and R are connected to form a substituted or unsubstituted cyclic heteroalkyl group. The compound has a high-activity inhibition effect on ROCK kinase.

Efficient synthesis of 6-amino-2-thiaspiro[3,3]heptane hydrochloride

A novel compound 6-amino-2-thiaspiro[3,3]heptane hydrochloride was synthesized in nine steps using 2,2-bis(bromomethyl)-1,3-propanediol as starting material, with an overall yield of 31%.

SYNTHESIS OF NEW CARBOCYCLIC ANALOGUES OF OXETANOCIN A AND OXETANOCIN G

The synthesis of cis-3-amino-1-cyclobutanemethanol has been performed in six steps (59.6percent yield) from cis-1,3-cyclobutanedicarboxylic anhydride.This allowed us to obtain two new carbocyclic analogues of oxetanocin A and oxetanocin G related to 7-deazaadenosine and 7-deazaguanosine.