4-Nitrobenzoic acid (R)-2,3-dihydroxypropyl ester

Base Information

• Chemical Name: 4-Nitrobenzoic acid (R)-2,3-dihydroxypropyl ester
• CAS No.: 74628-84-5
• Molecular Formula: C10H11NO6
• Molecular Weight: 241.2
• Mol file: 74628-84-5.mol

Synonyms:4-Nitro-benzoesaeure-((R)-2.3-dihydroxy-propylester);4-Nitro-benzoic acid (R)-2,3-dihydroxy-propyl ester;(2R)-2,3-dihydroxypropyl 4-nitrobenzoate;4-nitro-benzoic acid-((R)-2.3-dihydroxy-propyl ester);

Chemical Property of 4-Nitrobenzoic acid (R)-2,3-dihydroxypropyl ester

Chemical Property:

• PSA: 112.58000
• LogP: 0.62800

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitrobenzoic acid (R)-2,3-dihydroxypropyl ester

There total 5 articles about 4-Nitrobenzoic acid (R)-2,3-dihydroxypropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(R)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-nitrobenzoate (109111-28-6) → (R)-glycerol mono-p-nitrobenzoate (74628-84-5)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 60 ℃; for 6h;

Reference yield:

→ (R)-glycerol mono-p-nitrobenzoate (74628-84-5)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01222a020

Reference yield:

p-nitrobenzoic anhydride (902-47-6) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → (R)-glycerol mono-p-nitrobenzoate (74628-84-5) + (S)-1-(4-Nitrobenzoyloxy)-2,3-propanediol (121727-23-9)

Guidance literature:

With Candida antarctica; In 1,4-dioxane; at 15 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2004.09.033

upstream raw materials:

p-nitrobenzoic anhydride

glycerol

(R)-glycidyl 4-nitrobenzoate

4-nitro-benzoyl chloride

Downstream raw materials:

1,2-di-O-(3,5-dinitrobenzoyl)-3-O-p-nitrobenzoyl-sn-glycerole

3,5-Dinitro-benzoic acid (S)-2-hydroxy-3-(4-nitro-benzoyloxy)-propyl ester

(2S)-2,3-bis(nitrooxy)propyl 4-nitrobenzoate

(R)-2.3-dibenzoyloxy-1-(4-nitro-benzoyloxy)-propane