[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone

Base Information

• Chemical Name: [3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
• CAS No.: 6969-02-4
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 6969-02-4.mol

Synonyms:

Chemical Property of [3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone

Chemical Property:

• Vapor Pressure: 5.77E-07mmHg at 25°C
• Boiling Point: 411°Cat760mmHg
• Flash Point: 194°C
• Density: 1.213g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone

There total 11 articles about [3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-4-methoxychalcone (22252-15-9) → [3-(4-methoxyphenyl)oxiran-2-yl]phenylmethanone (6969-02-4,27729-95-9,82864-16-2)

Guidance literature:

With Br^(1-)*C₁₀H₁₈N₅O₂⁽¹⁺⁾; dihydrogen peroxide; sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 12h; optical yield given as %ee;

DOI:10.1016/j.molliq.2012.05.016

Reference yield: 91.0%

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → [3-(4-methoxyphenyl)oxiran-2-yl]phenylmethanone (6969-02-4,27729-95-9,82864-16-2)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In methanol; at 20 ℃; Cooling with ice;

DOI:10.1021/jo5022184

Reference yield: 84.0%

4-methoxy-benzaldehyde (123-11-5) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) → [3-(4-methoxyphenyl)oxiran-2-yl]phenylmethanone (6969-02-4,27729-95-9,82864-16-2)

Guidance literature:

1-chloroacetophenone; With C₃₁H₃₈N₂O₈; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-methoxy-benzaldehyde; In tetrahydrofuran; at 0 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c7cc06194c

upstream raw materials:

4-methoxy-benzaldehyde

α-bromoacetophenone

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

trans-4-methoxychalcone

Downstream raw materials:

3-(4-methoxyphenyl)-2-phenyl-2-hydroxypropanoic

5-(4-methoxybenzyl)-5-phenylimidazolidine-2,4-dione

N-phenacyltrimethylammonium chloride

1-[5-(4-Methoxy-phenyl)-3-phenyl-pyrazol-1-yl]-phthalazine

Refernces

• 1、 De Souza, Gabriela F. P.,Bonacin, Juliano A.,Salles, Airton G.. "Visible-Light-Driven Epoxyacylation and Hydroacylation of Olefins Using Methylene Blue/Persulfate System in Water". . p. 8331 - 8340. Retrieved 2018/07/21.
• 2、 Khosravi, Kaveh,Naserifar, Shirin,Mahmoudi, Boshra. "Metal-Free and Efficient Epoxidation of α,β-Unsaturated Ketones with 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as a Powerful Solid Oxidant". . p. 683 - 689. Retrieved 2017/06/19.