1-Propanone, 1-(2-methoxyphenyl)-2-methyl-

Base Information

• Chemical Name: 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-
• CAS No.: 74786-53-1
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 74786-53-1.mol

Synonyms:2-(2-Methylprop-1-enyl)-5-nitrothiophen;2-(2-methyl-propenyl)-5-nitro-thiophene;

Chemical Property of 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-

Chemical Property:

• PSA: 26.30000
• LogP: 2.53390

Purity/Quality:

1-(2-Methoxyphenyl)-2-methylpropan-1-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-

There total 15 articles about 1-Propanone, 1-(2-methoxyphenyl)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

isobutyrylpentamethylbenzene (2040-24-6) + methoxybenzene (100-66-3) → 4-methoxyisobutyrophenone (2040-20-2) + pentamethylbenzene, (700-12-9) + 1-(2-methoxyphenyl)-2-methylpropan-1-one (74786-53-1)

Guidance literature:

trifluoroacetic acid; for 5h; Heating;

DOI:10.1039/P29860000847

Reference yield: 90.0%

methanol (67-56-1) + 2-Methoxyacetophenone (579-74-8) → 1-(2-methoxyphenyl)-2-methylpropan-1-one (74786-53-1)

Guidance literature:

With potassium hydroxide; at 120 ℃; for 8h;

DOI:10.1002/cctc.201700907

Reference yield: 86.0%

methanol (67-56-1) + 1-(2-methoxyphenyl)prop-2-en-1-ol (58824-49-0) → 1-(2-methoxyphenyl)-2-methylpropan-1-one (74786-53-1)

Guidance literature:

With trifuran-2-yl-phosphane; palladium diacetate; lithium tert-butoxide; at 130 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.202101101

upstream raw materials:

2-methoxy-benzonitrile

isopropylmagnesium chloride

dimethylketene

methoxybenzene

Downstream raw materials:

C₁₅H₂₄O₂Si

(R)-2-methyl-1-(2-methoxyphenyl)-1-propanol

1-(2-methoxy-phenyl)-2-methyl-propan-1-ol

5-[(Z)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine

Refernces

• 1、 Shee, Sujan,Kundu, Sabuj. "Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol". . p. 6943 - 6951. Retrieved 2021/05/29.
• 2、 Chakrabarti, Kaushik,Maji, Milan,Panja, Dibyajyoti,Paul, Bhaskar,Shee, Sujan,Das, Gourab Kanti,Kundu, Sabuj. "Utilization of MeOH as a C1 Building Block in Tandem Three-Component Coupling Reaction". supporting information. p. 4750 - 4753. Retrieved 2017/09/22.